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Wintrobe's Clinical Hematology
Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
The Road to Jaramillo
This is the story, told here for the first time, of how an international cast of scientists produced the discoveries that brought about the plate-tectonics revolution. In preparing this book the author interviewed virtually all of the important contributors to that critical decade of research, 1957-66. Working in the tradition of history of science, he explores personal relationships, institutional support, and the rivalries and frictions between and within research groups.
Wintrobe's Clinical Hematology
With the 13th edition, Wintrobe’s Clinical Hematology once again bridges the gap between the clinical practice of hematology and the basic foundations of science. Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues. With the knowledge about gene therapy and immunotherapy expanding, new, up-to-date information about the process and application of these therapies is included. Likewise, the editors have completely revised material on stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors.
The Behavior of the Earth
Well over a century after Darwin gave biology its unifying theory of evolution, the earth sciences experienced a similar revolution and the theory of plate tectonics took hold. Plate tectonics posed the idea that the earth's crust is divided into a number of large, thin plates always in motion relative to one another. In The Behavior of the Earth, world-renowned earth scientist Claude Allègre sets forth the exciting events in this contemporary revolution from its first stirrings in the nineteenth-century and Alfred Wegener's original model of continental drift (1912) through the development of its full potential in modern plate-tectonic theory. Few scientific theories have been so all-encom...
Potential Theory in Gravity and Magnetic Applications
This text bridges the gap between the classic texts on potential theory and modern books on applied geophysics. It opens with an introduction to potential theory, emphasising those aspects particularly important to earth scientists, such as Laplace's equation, Newtonian potential, magnetic and electrostatic fields, and conduction of heat. The theory is then applied to the interpretation of gravity and magnetic anomalies, drawing on examples from modern geophysical literature. Topics explored include regional and global fields, forward modeling, inverse methods, depth-to-source estimation, ideal bodies, analytical continuation, and spectral analysis. The book includes numerous exercises and a variety of computer subroutines written in FORTRAN. Graduate students and researchers in geophysics will find this book essential.
Novel Developments in Stem Cell Mobilization
Recently the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development effective antagonists. One antagonist, plerixafor, is clinically approved now for stem cell mobilization of lymphoma and myeloma patients. This allows patients to receive potentially life-saving treatment which could not have been administered otherwise. Through early clinical studies it was recognized that CXCR4 antagonists also mobilize malignant hematopoetic cells, i.e. leukemia cells. In preclinical studies a sensitization of mobilized leukemic cells to standard cytotoxic chemotherapy could be shown. Clinical studies are under way. CXCR4 antagonists are an exciting new class of compounds which are also employed for the mobilization of angiogenic cells or for the treatment of solid tumors. In this book a concise review of the current status of knowledge and future developments will be presented.
Sessional Papers
"Report of the Dominion fishery commission on the fisheries of the province of Ontario, 1893", issued as vol. 26, no. 7, supplement.
