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Discover a proven method for making better investment choices The actions of politicians, regulators, and economic policy makers have an enormous impact on the financial markets. In Sectors and Styles, author Vincent Catalano offers an investment technique that takes these factors into account. He illustrates how you should index a portion of your stock portfolio to the market, while investing another portion in industry sectors that are likely to outperform the broader market. To determine "hot" sectors, Catalano provides a framework for analyzing government activity, the economy, and market activity. Through proper interpretation of these events, you'll learn how to outperform the markets, while mitigating downside risk.
Cancer is often associated with pain and is a frequent issue in patients with chemotherapy-induced neuropathy. The participation of patients in studies and their influence on study design is important. Patient support groups have been formed for several forms of cancer, and are helpful in dispensing advice. The treatment of cancer patients must include activities of daily living and quality of life. Often, palliative care and end-of-life care are part of the disease trajectory. As this book shows, patients do not have equal access to cancer treatment around the world, and often basic issues as diagnosis, treatment are lacking.
Drug development is a strictly regulated area. As such, marketing approval of a new drug depends heavily, if not exclusively, on evidence generated from clinical trials. Drug development has seen tremendous innovation in science and technology that has revolutionized the treatment of some diseases. And yet, the statistical design and practical conduct of the clinical trials used to test new therapeutics for safety and efficacy have changed very little over the decades. Our approach to clinical trials is steeped in convention and tradition. The large, fixed, randomized controlled trial methods that have been the gold standard are well understood and expected by many trial stakeholders. Howeve...
The papers presented in this volume report the striking progress X-ray diffraction has facilitated in the study of structural molecular biology. Coupled with the revival of the Laue method, the advent of high-intensity synchrotron radiation sources has made possible the rapid collection of X-ray crystallography data, thereby allowing protein and virus crystallography to progress from studies of equilibrium structures to time-resolved studies of structures at reaction stages. The book also details the many recent technological developments in physics, chemistry and biochemistry that have been critical for the full exploitation of the synchrotron Laue method in the study of dynamic events in crystals. Necessary future developments are discussed.
The first comprehensive book to cover all aspects of the last 25 years of PACAP (pituitary adenylate cyclase activating polypeptide) research, this book contains contributions from virtually all the leading researchers in the field, and addresses some of the following topics: evolutionary aspects of PACAP, distribution and occurrence of PACAP and its receptors, hormonal effects of PACAP, intracellular signaling, effects on cellular proliferation and differentiation, protective effects of PACAP, behavioral effects of PACAP, developmental aspects of PACAP, other physiological effects of PACAP (cardiovascular, thermoregulatory), human studies, drug design, metabolism and transport. This compendium can serve as an important reference for researchers and students in PACAP research and can also be a thorough introduction for those in related fields.
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Tribalism is a key evolutionary feature of humans, and the recent growth in tribal polarisation presents a serious challenge to our highly individualistic civilisation. This fascinating book examines the psychological origins and consequences of tribalism both in our private and in our public lives. The chapters explore how social, evolutionary, biological, and cognitive factors shape our tribal habits, featuring contributions from eminent international researchers. The chapters review the nature and origins of tribalism, the psychological mechanisms promoting tribalism, how tribal narratives can distort rationality and perceptions of reality, and the role of tribalism in politics and public...