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Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors
Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson's disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use. - Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors - Preclinical models in COMT inhibitor devlopment - Transgenic COMT mice – latest information summarized - Chemistry of COMT inhibitors and their design with molecular modelling - COMT gene and its regulation and relation to dopamine related diseases - Role of cofactor SAM regulation in relation to homocysteine - Nonclinical and clinical safety of COMT inhibitors summarized - Future prospects of COMT inhibitors in Parkinson's disease
Neurobiology of Acupuncture
This book summarises the recent development in acupuncture research and in particular, the neurobiology of acupuncture. It provides a focus but a diverse range of subjects covering many body systems. The first a few chapters discuss the basic principles of acupuncture, then its modulatory effects on nervous system such as induction of neurotrophin and neurogenesis in the brain. Late chapters explore the clinical effects and potential mechanisms of acupuncture on different conditions ranging from neurological diseases such as Parkinson's, Alzheimer's, and stroke, to psychiatric illnesses, insomnia, hypertension, gastrointestinal diseases and drug addiction. We believe this will promote the understanding acupuncture treatment and enhance acupuncture research in the future. - This volume of International Review of Neurobiology brings together cutting-edge research on the neurobiology of acupuncture - It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery
Neuro-inflammation in Neuronal Death and Repair
Neuroinflammation has been implicated recently in the pathogenesis of many neurodegenerative diseases. The cross-talk between neurons and non-neuronal cells seems to be a critical step in the progression of neurodegeneration and molecules that have a beneficial role may turn into harmful players. Thus, matrix metalloproteinases (MMPs), which are involved in axonal growth and regeneration as well as synaptic plasticity, may also have detrimental effects. Recent evidence has linked MMPs to conditions like ischemia, multiple sclerosis, Alzheimer's disease and suggested that, together with their role in the degradation of extracellular macromolecules, MMPs could work as important signalling mole...
Astrocytes
Astrocytes play diverse roles in central nervous system (CNS) function and dysfunction, and the connections that the astrocyte makes with other cells of the brain are essential for a variety of important neural tasks. Bringing together contributions from international experts at the top of their field, Astrocytes: Wiring the Brain emphasizes cellul
Neurodegenerative Diseases
Proceedings of the Fifteenth Washington International Spring Symposium held at The George Washington University, Washington, D.C., May 15-17, 1995
Neuroglia
Graduate students in neuroanatomy, neurochemistry, neurophysiology, and molecular neurobiology will find the book indispensable. It is also a vital companion for researchers in these fields as well as clinicians in neurology, neurosurgery, neuropathology, neuro-oncology, physiatry, and psychiatry."--BOOK JACKET.
Recent Advances in the use of Drosophila in Neurobiology and Neurodegeneration
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia. - Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research - Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered - All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Origins
First Published in 1994. Routledge is an imprint of Taylor & Francis, an informa company.
Neuroglia
Neuroglia, the third edition, is the long-awaited revision of the most highly regarded reference volume on glial cells. This indispensable edition has been completely revised, greatly enlarged, and enhanced with four-color figures throughout, all in response to the tremendous amount of new information that has accumulated since the previous edition seven years ago. Glial cells are, without doubt, the new stars in the neuroscience and neurology communities. Neglected in research for years, it is now evident that the brain only functions in a concerted action of all the cells, namely glia and neurons. Seventy one chapters comprehensively discuss virtually every aspect of normal glial cell anat...
