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Müller cells make up just 0.005% of the cells in our central nervous system. They do not belong to the more esteemed family of neuronal cells but to the glia, a family of cells that until recently were seen as mere filling material between the neurons. Now, however, all that has changed. Sharing the insights of more than a quarter century of research into Müller cells, Drs. Andreas Reichenbach and Andreas Bringmann of Leipzig University make a compelling case for the central role Müller cells play. Everyone agrees that the eye is a very special and versatile sense organ, yet it has turned out in recent years that Müller cells are peculiar and multipotent glial cells. In the retina of mos...
Retinal Glia
In 1851, Heinrich Müller discovered what he called “radial fibers” and what we now call Müller cells, as the principal glial cells of the vertebrate retina. Later on, other glial cell types were found in the retina, including astrocytes, microglia, and even oligodendrocytes. It turned out that retinal glial cells are essential constituents of the tissue. For instance, Müller cells appear to constitute the “core” of columnar units of clonally and functionally related groups of neurons. Their primary function is to support neuronal functioning by guiding the light towards the photoreceptor cells, removing excess neurotransmitter molecules from extracellular space, and performing eff...
Müller Cells in the Healthy and Diseased Retina
Müller cells may be used in the future for novel therapeutic strategies to protect neurons against apoptosis (for example, somatic gene therapy), or to differentiate retinal neurons from Müller/stem cells. Meanwhile, a proper understanding of the gliotic responses of Müller cells in the diseased retina, and of their protective vs. detrimental effects, is essential for the development of efficient therapeutic strategies that use and stimulate the neuron-supportive/-protective - and prevent the destructive - mechanisms of gliosis.
Astrocytic-neuronal-astrocytic Pathway Selection for Formation and Degradation of Glutamate/GABA
Endocrinological research early recognized the importance of intercellular interactions and realized the importance of glutamatergic and GABAergic signaling. In turn this signalling depends on elaborate interactions between astrocytes and neurons, without which neurons would be unable to produce, reuse and metabolize transmitter glutamate and GABA. Details of these subjects are described in this Research Topic by key investigators in this field. It focuses on the intricate and extremely swift pathway producing these amino acid transmitters from glucose in brain but also discusses difficulties in determining expression of some of the necessary genes in astrocytes and related processes in pancreatic islets. However, it does not discuss how closely associated astrocytes and neurons are anatomically, enabling these interactions. This is elegantly shown in this cover image, kindly provided by Professor Andreas Reichenbach (University of Leipzig, Germany).
Red Secularism
Red Secularism is the first substantive investigation into one of the key sources of radicalism in modern German, the subculture that arose at the intersection of secularism and socialism in the late nineteenth-century. It explores the organizations that promoted their humanistic-monistic worldview through popular science and asks how this worldview shaped the biographies of ambitious self-educated workers and early feminists. Todd H. Weir shows how generations of secularist intellectuals staked out leading positions in the Social Democratic Party, but often lost them due to their penchant for dissent. Moving between local and national developments, this book examines the crucial role of red secularism in the political struggles over religion that rocked Germany and fed into the National Socialist dictatorship of 1933. This title is part of the Flip it Open Programme and may also be available Open Access. Check our website Cambridge Core for details.
Neuroglia: Function and Pathology
Diverse specialised neuroglial cells guarantee the development, preservation, and health of the central nervous system, the peripheral nervous system, the enteric nervous system, and the special senses. In the central nervous system, it is the astrocytes, oligodendrocytes, and microglia that safeguard nerve cell function and integrity that controls all behaviours and encompasses the cerebral cortex of the brain which is the root of humanity. In the peripheral nervous system, Schwann cells play the leading role, together with satellite glial cells of the sensory and autonomic ganglia, ensuring correct communication between the organs and tissues with the brain and the spinal cord. In the ente...
Reichspersonal
Was hat das Alte Reich im Innersten zusammen gehalten? Waren es die Reichsinstitutionen wie beispielsweise das Reichskammergericht, der Reichshofrat und der Reichstag? Oder waren es die Reichsgrundgesetze wie der Westfälische Friede? Einen entscheidenden integrativen Faktor des Alten Reiches stellten gewiss die Personen und Personengruppen dar, die Aufgaben und Funktionen für Kaiser und Reich wahrnahmen. Inwieweit besaßen diese Personen eine spezifische Mentalität, die über das Zugehörigkeitsgefühl zu einer Reichsinstitution hinausging? Diesen und anderen Fragen gehen die Autoren nach, wobei das Spektrum der Beiträge von den Reichskammergerichtsboten, über Anwälte an den beiden höchsten Gerichten bis zu den kaiserlichen Kommissaren am Reichshofrat reicht.
Development and Organization of the Retina
Development and Organization of the Retina offers an invaluable survey of contemporary research issues and methods dealing with the retina and retinal projections. The book's 19 chapters report on investigations into two areas: research into the organization of the mature retina and work on developmental issues. A sampling of chapter topics includes -- embryonic patterning of cone subtypes in the mammalian retina -- synaptic transmission between retinal neurons -- scaling the retina, macro and micro -- retinal ganglion cell axonal transport, and more.
A Neuroscientist Looks at Robots
The book, written for a general educated public, compares the most important elements of the human nervous system to the corresponding capacities of robots. Crucial are the areas of activities for which the constraints limiting human and robot performances are much different. Those areas offer opportunities for synergies. The book argues that we now understand mechanisms for emotional feelings in the human brain so well that we will be able to program robots to act as though they also have emotion. Written in a clear and open fashion by an expert neuroscientist, the book will appeal to interested lay readers in addition to neuroscientists and computer scientists. Contents:IntroductionRobots ...
Neurobiology and Clinical Aspects of the Outer Retina
This book deals with the cellular biology, biochemistry and physiology of photoreceptors and their interactions with the second-order neurons, bipolar and horizontal cells. The focus is upon the contributions made by these neurons to vision. Thus the basic neurobiology of the outer retina is related to the visual process, and visual defects that could arise from abnormalities in this part of the retina are highlighted in the first 16 chapters. Since all vertebrate retinas have the same basic structure and physiological plan, examples are given from a variety of species, with an emphasis upon mammals, extending to human vision. The last four chapters approach the problem from the other end. T...
