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Interest in recombinant antibody technologies has rapidly increased because of its wide range of possible applications in therapy, diagnosis, and especially, cancer treatment. The possibility of generating human antibodies that are not accessible by conventional polyclonal or monoclonal approaches has facilitated the development of antibody engineering technologies. This manual presents a comprehensive collection of detailed step-by-step protocols, provided by experts. The text covers all basic methods needed in antibody engineering as well as recently developed and emerging technologies.
Tabulation and analysis of amino acid and nucleic acid sequences of precursors, v-regions, c-regions, j-chain, T-cell receptors for antigen, T-cell surface antigens, l-microglobulins, major histocompatibility antigens, thy-1, complement, c-reactive protein, thymopoietin, integrins, post-gamma globulin, -macroglobulins, and other related proteins.
This book constitutes the joint refereed proceedings of six workshops on evolutionary computing, EvoWorkshops 2004, held together with EuroGP 2004 and EvoCOP 2004 in Coimbra, Portugal, in April 2004. The 55 revised full papers presented were carefully reviewed and selected from a total of 123 submissions. In accordance with the six workshops covered, the papers are organized in topical sections on evolutionary bioinformatics; evolutionary computing in communications, networks, and connected systems; hardware optimization techniques; evolutionary computing in image analysis and signal processing; evolutionary music and art; and evolutionary algorithms in stochastic and dynamic environments.
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Evolutionary computation (EC) techniques are e?cient nature-inspired pl- ning and optimization methods based on the principles of natural evolution and genetics. Due to their e?ciency and the simple underlying principles, these methods can be used for a large number of problems in the context of problem solving,optimization,andmachinelearning. Alargeandcontinuouslyincreasing number of researchers and practitioners make use of EC techniques in many - plication domains. The book at hand presents a careful selection of relevant EC applications combined with thorough examinations of techniques for a successful application of EC. The presented papers illustrate the current state of the art in the...