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Handbook of Global Tuberculosis Control
This ambitious reference surveys worldwide efforts at controlling the spread of tuberculosis, with special emphasis on the developing world. Case studies from China, Pakistan, Nigeria, Indonesia, and other frontline countries demonstrate a wealth of information on clinical, cultural, socioeconomic, and other relevant factors. This compilation provides a valuable resource for creating successful intervention and prevention strategies. State-of-the-science snapshots pinpoint where short- and long-term initiatives stand today, from early detection and vaccination programs to new genetic technologies and drug therapies. This diverse group of perspectives and approaches offers innovative paths to...
Genetic Determinants of Human Longevity
In the last two decades, due to the continuous increase of lifespans in Western societies, and the consequent growing of the elderly population, have witnessed an increase in the number of studies on biological and molecular factors able to promote healthy aging and reach longevity. The study of the genetic component of human longevity demonstrated that it accounts for 25% of intra population phenotype variance. The efforts made to characterize the genetic determinants suggested that the maintenance of cellular integrity, inflammation, oxidative stress response, DNA repair, as well as the use of nutrients, represent the most important pathways correlated with a longer lifespan. However, alth...
Microbial Transmission
Microbial transmission, the processes by which microbes transit to new environments, is a significant and broad-reaching concept with applications throughout the biological sciences. This collection of reviews, edited by an international team of experts studying and working across a range of disciplines, explores transmission not just as an idea in disease but as a fundamental biological process that acts in all domains of nature and exerts its force on disparate size scales, from the micro to the macro, and across units of time as divergent as a single bacterial replication cycle and the entire course of evolution. In five sections, this overview Defines the concept of transmission and cove...
Transposable Elements
The volume presents a small selection of state-of-the-art approaches for studying transposable elements(TE). Chapters guide readers through HTS-based approaches, bioinformatic tools, methods to studyTE protein complexes, and the functional impact on the host. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Transposable Elements: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.
The Encyclopedia of Vitamin E
Vitamin E is an important dietary constituent which helps in the defence against cellular damage. The process of its absorption from food and its utilization by the body is an intricate series of reactions. It is also used therapeutically in treating numerous diseases and conditions such as skin damage and the prevention of pathological lesions in major organs, and has been shown to be an important factor in preventing heart disease and cancer. Over 100 chapters from international contributors make this book the most comprehensive reference work in describing both the positive and negative effects and actions of Vitamin E. Chapters are divided into subsections which cover: nomenclature, biochemical, physical and chemical aspects of vitamn E related compounds; dietary and nutritional influences and effects; cocktails, anti-oxidants mixtures and novel analogues; general physiological systems, metabolism and metabolic stress; brain, neurological and optical systems; reproductive systems, fetus and infant; musculo-skeletal systems and exercise; cardiovascular and pulmonary systems; skin; hepatic, nephrotic and gastrointestinal systems; immune and haematological systems and cancer.
Alkoxysilanes and the Consolidation of Stone
Stone is one of the oldest building materials, and its conservation ranks as one of the most challenging in the field. The use of alkoxysilanes in the conservation of stone can be traced as far back as 1861, when A. W. von Hoffman suggested their use for the deteriorating limestone on the Houses of Parliament in London. Alkoxysilane-based formulations have since become the material of choice for the consolidation of stone outdoors.^l This volume, the first to cover comprehensively alkoxysilanes in stone consolidation, synthesizes the subject's vast and extensive literature, which ranges from production of alkoxysilanes in the nineteenth century to the extensive contributions from sol-gel sci...
Latest Breakthroughs in the Treatment of Atopic Dermatitis
The last decade has ushered in an exciting new era in the pathophysiology and treatment of atopic dermatitis (AD). In this book, we shed light on the latest breakthroughs in systemic treatments for moderate-to-severe AD. In particular, we focus on the role and indication of JAK inhibitors, the role of natural killer cells in opening doors to new therapies, newly validated treatments, disease-based community data of current treatments, and the most recent clinical efficacy data of novel agents that have revolutionized the management of moderate-to-severe AD.
