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Driving Next-generation Autophagy Researchers Towards Translation (DRIVE), an International PhD Training Program on Autophagy
Abstract: The European autophagy consortium Driving next-generation autophagy researchers towards translation (DRIVE) held its kick-off meeting in Groningen on the 14th and 15th of June 2018. This Marie Skłodowska-Curie Early Training Network was approved under the European Union's Horizon 2020 Research and Innovation Program and is funded for 4 years. Within DRIVE, 14 European research teams from academia and industry will train 15 PhD students through applied, cross-disciplinary and collaborative macroautophagy/autophagy research. The goal of DRIVE is to stimulate applied approaches in autophagy research and provide training towards translation, while advancing our knowledge on autophagy in specific physiological and pathological states. The strong focus on translation will prepare the PhD students to be at the forefront to exploit autophagy for the development of therapies directly benefitting patients. Thereby, DRIVE will contribute to filling the educational gap that currently exists between academia and industry, and will prepare its PhD students for alternative and highly flexible professional paths
Autophagy of the Nervous System
What is autophagy? Why would neurons digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as an accomplice to cell death in others? By what mechanisms are autophagy-related processes dysregulated in neurological diseases, and are there therapeutic strategies to correct or compensate for their dysfunction? This book provides an expert view of major concepts in autophagy research with a focus on autophagy in neurons. Experimental evidence for evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented, including recent data on braking mechanisms. Areas of interse...
Kjærlighet og mørke
Hvordan kunne den unge skuespillerinnen Marie Andersen falle for den langt eldre, og etter hvert sjalu og kontrollerende Knut Hamsun? Med Anne Hege Simonsens biografi trer nå Marie Hamsun ut av den verdenskjente forfatterens skygge. Biografien starter i Elverum der Anne Marie Andersen ble født i 1881 og ender med hennes død på Nørholm utenfor Grimstad i 1969. Tiden i Nordland var Maries lykkeligste periode i livet. Da Knut flyttet henne og familien til Nørholm, opplevde hun det som et svik. Tidligere upublisert materiale og ukjente brev fra Marie belyser ekteparets lidenskapelige kjærlighet. Kildene viser også hvordan mellomkrigstiden og nasjonalsosialismen formet henne ideologisk. M...
Ionizing Radiation and the Immune Response - Part A
Ionizing Radiation and the Immune Response, Volume 376, Part A reviews the latest updates on the immune response induced by ionizing radiations. Sections discuss NK functions in radio-induced immune response, TRT and immune response, Radio-induced immune response and lipid metabolism, Effect of protons and heavy ions on immune response, Effect of flashtherapy and mini beam on immune response, Radio-induced lymphopenia, CT to potentiate radio-induced immune response, Impact of RT on healthy tissues (inflammation), Radio-induced macrophagic response, To use nanoparticles and ionizing radiations to modulate immune response: opinion of the chemist, biologist and clinician, and more. Additional s...
Viral Vectors in Cancer Immunotherapy
Viral Vectors in Cancer Immunotherapy, Volume 379 in the International Review of Cell and Molecular Biology presents the latest on cancer immunotherapy and how it has transformed cancer treatment through advances in immune checkpoint inhibitors and adoptive cell therapy. Chapters in this new release include Past, present and future of viral vectors in cancer immunotherapy, Alphaviruses in cancer immunotherapy, Adenoviral-based cancer gene therapy, Armored modified vaccinia Ankara in cancer immunotherapy, Strategies of Semliki Forest virus in immuno-oncology, Maraba virus in cancer immunotherapy, Oncolytic viruses in hematological malignancies, Oncolytic virus for cancer therapies: Overview a...
Circulating Tumor Cells, From Biotech Innovation to Clinical Utility Part A
"Circulating Tumor Cells, from biotech innovation to clinical utility" provides an overview of the most recent technological and clinical advances with regards to the study of circulating tumor cells (CTCs) in solid tumors. The volumes cover studies on CTCs in breast, prostate, colorectal and lung cancer, with a focus on clinical utility, and also include methodological and biological topics such as CTC culture, multi-omic characterization of CTCs, atypical CTC populations and interaction between CTCs and immunity. Provide a summary of the latest advances of CTC studies in the most common solid tumors Give an overview of the most advanced methods for CTC characterization and functional analysis Present new perspective on the clinical utility of CTCs
Y is for Yes to Everything - 10 Erotic Short Stories
“I tried to pull back a little so my breasts weren’t so pressed up against the blonde one, but the music pulled us closer together. His leg slid between mine. It had an unexpected effect. Something opened up and a warm, tickling sensation spread up through my abdomen. I rested my head on his chest and he kissed my hair, saying something in French I couldn’t understand. For the first time that evening, I didn’t think of Felix and even when I did, I didn’t pull away. I knew it was wrong, but I stayed, pressed up against this man I’d barely said a word to, feeling his thigh muscles against my crotch.” – She moves in mysterious ways. Part of the erotic alphabet series, ‘Y is fo...
Epigenetic Regulation of Cancer-Part C
Epigenetic Regulation of Cancer, Part C, Volume 389 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic biomarkers in breast cancer, Contribution of epigenetics to virus-driven cancer, Cancer metabolism and epigenetics, Technologies for epigenome editing, Epigenetics and cancer stemness, Epigenetic modifications in obesity-associated cancers, Epigenetics in cf microRNA in blood of solid tumors, Integrative analysis of transcriptome, chromatin accessibility, cell surface antigen in single cell level for AML, and more. Additional chapters cov...
Hands, Lips, Eyes: 5 Erotic Series And Other Thrilling Erotic Short Stories
‘Hands, Lips, Eyes: 5 Erotic Series And Other Thrilling Erotic Short Stories’ is a collection from LUST that allows you to experience exciting sexual encounters vicariously through a range of fantasies and tales. From friends with benefits to fun in Paris, from hot and sexy summers to bondage and games, find what pleasures you. This collection includes: ‘Summer Sex 1: The Bus’, ‘Summer Sex 2: The Beach’, ‘Summer Sex 3: The Park’, ‘All About Hands’, ‘Preview’, ‘Opening night’, ‘The Medical Interns’, ‘Delirium', Yukako’, ‘Friends with Benefits: Through Tony's Eyes’, ‘Friends with Benefits: Through Jack's Eyes’, ‘Madame 1: Foreplay’, ‘A Dream of Paris’, ‘Fearless: A Dream of Paris 2’, ‘The Waitress, 'Tip’, ‘March’, ‘Snow’, ‘8. Arrondissement’, ‘She moves in mysterious ways’, ‘Dangerous’, ‘Games’, and ‘Tie Me Up’.
