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Immunomodulating Drugs for the Treatment of Cancer
Immunomodulating Drugs for the Treatment of Cancer provides a comprehensive resource for clinicians and researchers regarding immunomodulatory (IMiDs) drugs and their rapidly emerging role in cancer medicine. This new class of anticancer agents has made a tremendous impact on the treatment of patients with various malignant diseases, including blood cancers and several cancers of the solid organs. Their popularity in prescribing is based on several important characteristics including: (1) oral bioavailability, (2) non-chemotherapeutic, (3) extremely well-tolerated in all age groups, (4) ability to activate patient's own immune response against cancer, (5) ease of combination with other agents such as chemotherapy resulting in higher responses as well as (6) variability of anticancer activity.
Myeloma Therapy
Therapeutic options for patients with myeloma have dramatically changed over the past 10 years. Beginning with the advances in therapy resulting from the use of high-dose therapy and autologous bone marrow or stem cell tra- plant, we have more than doubled the median survival for patients as a whole, and have now have a wealth of different biology -based treatment approaches for our patients in all disease stages. This book represents state-of-the-art information from many of the leaders in the plasma cell disorders world. Sections focusing on disease pathogenesis and biology, chemotherapy-based approaches, immune -based therapies, currently approved novel agents, developing targets, support...
Music in Seventeenth-Century Naples
The most important figure of seventeenth-century Neapolitan music, Francesco Provenzale (1624-1704) spent his long life in the service of a number of Neapolitan conservatories and churches, culminating in his appointment as maestro of the Tesoro di S. Gennaro and the Real Cappella. Provenzale was successful in generating significant profit from a range of musical activities promoted by him with the participation of his pupils and trusted collaborators. Dinko Fabris draws on newly discovered archival documents to reconstruct the career of a musician who became the leader of his musical world, despite his relatively small musical output. The book examines Provenzale's surviving works alongside...
The Meriam House
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Through Carmela's Eyes
This is the story of a young girl, an Italian immigrant, who was brought to America in hopes of a better life. Times were hard and her parents were forced to take her out of school, at age twelve and send her to work in one of the woolen mills in Lawrence Massachusetts. While there, she endured a devastating accident that would forever alter her life and that of her family. The repercussions would extend far beyond anything that could be imagined. Carmela Teoli, after spending seven months in a hospital, would go on to testify to a Congressional Committee about the conditions under which she, and the other children, had been forced to work. Her words had the power to influence many people in...
Italians in Haverhill
Italian immigrants became permanent residents of Haverhill in the 1870s. The original Genoese first drew their relatives and friends from their home area to join them. Over the next few decades, they were joined by families from the central province of Abruzzi and from the towns and villages around Naples. Immigrants from parts of southern Italy, such as Calabria and Apulia and Sicily, settled here. All of the Italians, whether northern or southern, brought with them their culture, their vitality, their love of music, and their close family ties. Using over two hundred thirty vintage photographs, Italians in Haverhill takes a photographic walk through the exciting history of these immigrants. The images bring back to life representatives of more than two hundred families, whose descendants still live in the area. Here are the fruit sellers and shoe workers, the mothers and their children, the ball players and the musicians, the lawyers and doctors, and the bankers and civic leaders who make up the rich heritage of this important ethnic group.
Finding Frank
A chance encounter; an unusual request; two lives inexorably transformed. When self-absorbed Brooke Blake uncharacteristically sheds her narcissistic armor, she discovers that the hand we lend may pave the way to our own redemption. Finding Frank is a perplexing hall of mirrors where every image reflects agonizing - though liberating - secrets. Frank was a Silver Orphan, one of 11 million seniors in the U.S. who live alone. Most still have family members, but about 15 percent of seniors who need care have no family support. By 2030, the number of people over age 65 will soar to 71.5 million - one in every five Americans. Yet, over half of America's communities have not initiated preparation to deal with the aging population. Unless this situation is addressed, we will soon be engulfed in a tidal wave of Silver Orphans.
Handbook of Synthetic Photochemistry
Unique in its focus on preparative impact rather than mechanistic details, this handbook provides an overview of photochemical reactions classed according to the structural feature that is built in the photochemical step, so as to facilitate use by synthetic chemists unfamiliar with this topic. An introductory section covers practical questions on how to run a photochemical reaction, while all classes of the most important photocatalytic reactions are also included. Perfect for organic synthetic chemists in academia and industry.
Textbook of Medical Oncology
Effective care of the cancer patient increasingly involves systemic treatment, and as the range of available therapeutic agents continues to expand, the medical oncologist must be fully aware of the rationale for choosing specific drugs and combinations. Textbook of Medical Oncology, 4th edition, is written by a highly acclaimed list of internation
Multiple Myeloma
Multiple Myeloma: The second issue of Emerging Cancer Therapeutics focuses on multiple myelomas also known as plasma cell myeloma, KahlerÌs Disease and myelomatosis. It is estimated that over 20,000 new cases are diagnosed each year with over 10,000 people dying from these malignancies. Multiple myelomas are highly treatable but rarely curable. Thus it is crucial for the practitioner to be up-to-date on the latest insights regarding their management. Management options and outcomes for individuals with multiple myelomas improved dramatically with the introduction of chemotherapy. Even further improvements in prognosis have occurred because of the introduction of newer therapies such as puls...
