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Topics in Stereochemistry
This seminal series, first edited by Ernest Eliel, responsible for some of the major advances in stereochemistry and the winner of the ACS Priestley Medal in 1996, provides coverage of the major developments of the field of stereochemistry. The scope of this series is broadly defined to encompass all fields of chemical and biological sciences that are founded on molecular and supramolecular interactions. Insofar as chemical, physical, and biological properties are determined by molecular shape and structure, the importance of stereochemistry is fundamental to and consequential for all natural sciences. Topics in Stereochemistry serves as a multidisciplinary series that enriches all of chemis...
Organophosphorus Chemistry
Organophosphorus Chemistry provides a comprehensive annual review of the literature. Coverage includes phosphines and their chalcogenides, phosphonium salts, low coordination number phosphorus compounds, penta- and hexa-coordinated compounds, tervalent phosphorus acids, nucleotides and nucleic acids, ylides and related compounds, and phosphazenes. The series will be of value to research workers in universities, government and industrial research organisations, whose work involves the use of organophosphorus compounds. It provides a concise but comprehensive survey of a vast field of study with a wide variety of applications, enabling the reader to rapidly keep abreast of the latest developme...
Fluorocarbon and Related Chemistry
Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The A...
Integration of Pharmaceutical Discovery and Development
In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and m...
Advances in Heterocyclic Chemistry
The definitive serial in the field -- since 1960. Provides up-to-date material on a fast growing and highly topical subject area Contains the latest research covering a wide variety of heterocyclic topics Written by leading authorities and designed as a handbook for students and industry and academic researchers
Asymmetric Synthesis V4
Asymmetric Synthesis, Volume 4: The Chiral Carbon Pool and Chiral Sulfur, Nitrogen, Phosphorus, and Silicon Centers describes the practical methods of obtaining chiral fragments. Divided into five chapters, this book specifically examines initial chiral transmission and extension. The opening chapter describes the so-called chiral carbon pool, the readily available chiral carbon fragments used as building blocks in synthesis. This chapter also provides a list of 375 chiral building blocks, along with their commercial sources, approximate prices, and methods of synthesis. Schemes involving almost 1,300 structures and the use of chiral building blocks to prepare alkaloids, arachidonic acid metabolites, compounds with chemotherapeutic and pharmacological activity, insect pheromones, sugars, vitamins, terpenoids, and miscellaneous compounds are also included in this text. The remaining chapters provide a similar overview of the chemistry of compounds chiral at sulfur, phosphorus, nitrogen, and silicon. Synthetic chemists and researchers, especially those engaged in pharmaceutical research and specialty chemicals production, will find this book invaluable.
Advances in DNA Sequence-Specific Agents
This series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro) for the study of these critical interactions. As our understanding of the genome and proteome expands, general developments in the field of DNA sequence specific interaction are likely to play an increasingly important role. Accordingly, manuscripts have been solicited from experts covering a diverse range of fields, reflecting the cross-disciplinary and dynamic nature of the series.Volume 4 describes work on the modification of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective binders, bulged DNA microenvironments as molecular targets, DNA sequence specific binding by short peptides and the analysis of DNA-protein interactions using DNase I footprinting methodology.Features include:• Expert contributors from the Biomedical world• Emerging areas of drug design and therapeutic applications• Nucleic acid-protein interactions• Color graphics of molecular modeling analyses• New and emerging methodologies
Visible Light-Driven Organic Synthesis
Visible Light-Driven Organic Synthesis covers the recent cutting-edge investigations in the field of visible light– driven organic synthesis in a single comprehensive volume. It provides information on rigorously selected reaction schemes and covers new reactions and new methods under visible light photocatalysis. It enlists more than 100 important synthetic strategies/methodologies with particular emphasis on useful reactions for organic synthesis under the mild reaction conditions reported in recent times involving carbon–carbon (C–C) and carbon–heteroatom bond–forming reactions, resulting in a wide spectrum of chemical compounds, providing an outstanding source of information co...
Superacid Chemistry
The chemistry of superacids has developed in the last two decades into a field of growing interest and importance. Now available in a new expanded second edition, this definitive work on superacids offers a comprehensive review of superacids and discusses the development of new superacid systems and applications of superacids in the promotion of unusual reactions. Covering Bronsted and Leurs superacids, solid superacids, carbocations, heterocations, and catalyzed reactions, this timely volume is invaluable to professionals, faculty, and graduate students in organic, inorganic, and physical chemistry.
Phosphorus
Over two decades have passed since the fifth edition of Phosphorus: Chemistry, Biochemistry and Technology. Major advances in chemistry, materials science, electronics, and medicine have expanded and clarified the role of phosphorus in both our everyday appliances and groundbreaking research. Significantly expanded, updated, and reorganized, this sixth edition organizes and explains vital phosphorus research and relevant information available in highly specialized reviews and references on select related topics. An authoritative and comprehensive review of phosphorus chemistry and related technology, Phosphorus: Chemistry, Biochemistry and Technology covers historical, academic, industrial, ...
