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Brain Development
This is the first book about both normal development of the nervous system and how early exposure to alcohol and nicotine interferes with this development. The developing nervous system is highly dynamic and vulnerable to genetic and epigenetic factors that can be additive or synergistic. Disruption of normal brain development leads to an array of developmental disorders. One of the most common of these is mental retardation, the prime cause of which is prenatal exposure to alcohol. As chapters in this book show, alcohol has direct effects on the developing neural system and it affects genetic regulation. Another common neurotoxin is nicotine, and it is discussed in this book for three reaso...
Protein Interaction Networks in Health and Disease
The identification and mapping of protein-protein interactions (PPIs) is a major goal in systems biology. Experimental data are currently produced in large scale using a variety of high-throughput assays in yeast or mammalian systems. Analysis of these data using computational tools leads to the construction of large protein interaction networks, which help researchers identify novel protein functions. However, our current view of protein interaction networks is still limited and there is an active field of research trying to further develop this concept to include important processes: the topology of interactions and their changes in real time, the effects of competition for binding to the ...
Chromatin Protocols
More than 40 years after the discovery of the nucleosome as the fun- mental unit of chromatin, the multifaceted problem of how variations in ch- matin structure affect the activity of the eukaryotic genome has not been solved. However, during the past few years research on chromatin structure and fu- tion has gained considerable momentum, and impressive progress has been made at the level of concept development as well as filling in crucial detail. The structure of the nucleosome has been visualized at unprecedented reso- tion. Powerful multisubunit enzymes have been identified that alter histone/ DNA interactions in ways that expose regulatory sequences to factors initi- ing and regulating ...
The Making of Migrant Entrepreneurs
Given the diversification of global migration patterns, the increased importance attributed to knowledge and innovation for economic development, and the rise of social policy regimes that emphasise self-responsibility, migrant entrepreneurship has become a widely discussed form of migrant incorporation in both policy and social sciences. Particularly in North America and Europe, policy advisors have drafted special programmes and regulations aimed at self-employed migrants, while social scientists have also come up with a vast body of research, although it has not been exempt from certain controversies and biases. Migrant entrepreneurship has frequently been associated either with rags-to-r...
Arb
"For the first time, an informative multi-faceted picture of the Bern architectural office arb is sketched out in this book by architectural critics, photographers and the architects themselves. Typical arb-buildings are presented from various perspectives: for example, the Merzenacker and Hintere Aumatt developments, the Freies Gymnasium Bern, the tower on Ulmizberg, and the Brunnadern and Kalchacker houses." "The systematically structured catalog of work documents over sixty buildings and projects from 1969 to the present."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
High-Speed Networking
Leading authorities deliver the commandments for designing high-speed networks There are no end of books touting the virtues of one or another high-speed networking technology, but until now, there were none offering networking professionals a framework for choosing and integrating the best ones for their organization's networking needs. Written by two world-renowned experts in the field of high-speed network design, this book outlines a total strategy for designing high-bandwidth, low-latency systems. Using real-world implementation examples to illustrate their points, the authors cover all aspects of network design, including network components, network architectures, topologies, protocols, application interactions, and more.
Heterogeneous Network Quality of Service Systems
Heterogeneous Network Quality of Service Systems will be especially useful for networking professionals and researchers, advanced level students, and other information technology professionals whose work relate to the Internet.
BioMath in the Schools
Even though contemporary biology and mathematics are inextricably linked, high school biology and mathematics courses have traditionally been taught in isolation. But this is beginning to change. This volume presents papers related to the integration of biology and mathematics in high school classes. The first part of the book provides the rationale for integrating mathematics and biology in high school courses as well as opportunities for doing so. The second part explores the development and integration of curricular materials and includes responses from teachers. Papers in the third part of the book explore the interconnections between biology and mathematics in light of new technologies in biology. The last paper in the book discusses what works and what doesn't and presents positive responses from students to the integration of mathematics and biology in their classes.
