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The intention of this book is to provide a comprehensive and contemporary review of the biology of sensory nerves. The book is unique, as it comprehensively covers the role of sensory nerves across many therapeutic areas.
Taking a comprehensive approach in which all aspects of the vagal afferent system are considered, from the terminals in the visceral tissues to the neural pathways within the central nervous system, this extensive text reviews the development, neurochemistry, anatomy, biophysics, pharmacology, and physiology of the vagal afferent nerves. The author
Boasting a worldwide reputation as the leading text in allergy and immunology, Middleton's Allergy continues its steadfast tradition of providing comprehensive coverage of state-of-the-art basic science, as well as authoritative guidance on the clinical concepts of day-to-day diagnosis and management of allergic disorders. Offering timely information that’s suited for clinicians and researchers alike, Middleton’s is a user-friendly and versatile source for the knowledge you need to provide optimal care to your patients! "A valuable source of reference and pre-sifted information ...the editors are to be commending in keeping the book up-to-date and clinically valuable." Reviewed by: Imnun...
Focusing specifically on the inter-relationship between the nose and the lungs, this reference examines the structural connections between the upper and lower airways and explores the microscopic and gross anatomy of the respiratory tract. Considering functional relationships, as well as human and animal models of disease, this source delivers arti
According to the World Health Organization (WHO), COVID-19 and Long COVID will remain conditions of great concern for medical practitioners for the foreseeable future. Mainstream treatments recommended for less severe cases of COVID-19 infection include isolation and taking over-the-counter or prescription painkillers, while more severe cases may require hospitalization and treatments such as ventilation. The long-term impact of post-viral conditions such as Long COVID is only beginning to emerge, and so far no effective biomedical treatment methods have been identified.Mainstream treatment is effective, but to what extent? Is there another course of treatment available for patients who do n...
Cough is the most familiar symptom of respiratory disease, and a problem which general practitioners must deal with on a daily basis. This timely volume draws together a wealth of recent research into the mechanisms, pharmacology and therapies for cough, and places these in clinical context. The text incorporates guidelines on the most common causes of cough, discusses treatments and pitfalls in management, summarizes current research on physiology, pharmacology and treatment of cough, and gives practical advice on diagnosis and management issues for the clinician. Cough: Causes, Mechanisms and Therapy is the most comprehensive, up-to-date account of the subject. It will update clinical and basic medical scientists, and promote future research. Readers are encouraged to implement the clinical implications of the discussion into routine practice. This volume will appeal to all those involved in the treatment of respiratory disease, particularly those in hospital respiratory units, and will also be of use to interested general practitioners.
An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.
Addressing the relationships between gastroesophageal reflux and airway diseases, this pioneering reference is the only single source that serves as an intensive review of the subject, providing a large spectrum of information facilitating proper diagnosis and treatment of GERD and GERD-related disorders. Focusing on dentition, upper airway disease, cough, and lower airway disease, and presented in a format ideal for primary care providers and specialists, Gastroesophageal Reflux Disease and Airway Disease analyzes practical, in-office approaches to diagnosis provides guidelines for diagnostic modalities and treatment in all age groups clarifies when to consider surgical procedures highlight...
Both acute and chronic cough are responsible for a significant number of ambulatory medical visits annually. The recent comprehensive understanding that “cough is a reflection of underlying disease pays tribute to the multifactorial causes, as well recognition of the respiratory and upper digestive tract as a “physiologic unit. This publication highlights the advances made in managing cough and brings these to otolaryngology practitioners in a concise forum, as well as presenting issues of special interest to laryngologists such as paradoxical vocal fold motion, disordered breathing, irritable larynx, evolution of the vagus as a protective circuit, the importance of cough in deglutition, and surgical interventions. Some of the topics include: The cough reflex, sensory receptors, and neurogenic mediators; Mucus and mucins; Cough and Swallowing dysfunction; Cough due to asthma, cough-variant asthma, and nonasthmatic eosinophilic bronchitis; Occupational, environmental, and irritant induced cough; Pharmacologic management; Unexplained cough; Cough in the pediatric population; and Rhinogenic laryngitis, cough and the unified airway; among others.
The airways and lungs are innervated by both sympathetic and parasympathetic nerves. Cholinergic parasympathetic innervation is well conserved in the airways while the distribution of noncholinergic parasympathetic and adrenergic sympathetic nerves varies considerably amongst species. Autonomic nerve function is regulated primarily through reflexes initiated upon bronchopulmonary vagal afferent nerves. Central regulation of autonomic tone is poorly described but some key elements have been defined.