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Engineering Simulations as Scientific Instruments: A Pattern Language
This book describes CoSMoS (Complex Systems Modelling and Simulation), a pattern-based approach to engineering trustworthy simulations that are both scientifically useful to the researcher and scientifically credible to third parties. This approach emphasises three key aspects to this development of a simulation as a scientific instrument: the use of explicit models to capture the scientific domain, the engineered simulation platform, and the experimental results of running simulations; the use of arguments to provide evidence that the scientific instrument is fit for purpose; and the close co-working of domain scientists and simulation software engineers. In Part I the authors provide a managerial overview: the rationale for and benefits of using the CoSMoS approach, and a small worked example to demonstrate it in action. Part II is a catalogue of the core patterns. Part III lists more specific “helper” patterns, showing possible routes to a simulation. Finally Part IV documents CellBranch, a substantial case study developed using the CoSMoS approach.
Proceedings of the Joint 3rd International Conference on Bioinformatics and Data Science (ICBDS 2022)
This is an open access book. We are pleased to announce our 3rd International Conference on Bioinformatics and Data Science (ICBDS – 2022) and 9th International Conference on Public Mental Health and Neurosciences (ICPMN – 2022) which was a unique conference where we connectted Biological Function through Computational Genomics to the world of integrated medicine and therapeutics. Functional genomics is a field of molecular biology that attempts to describe gene (and protein) functions and interactions. This science aims to understand the complex relationship between genotype and phenotype on a global (genome-wide) scale of different biological processes. Most researchers now study genes...
European Language Grid
This open access book provides an in-depth description of the EU project European Language Grid (ELG). Its motivation lies in the fact that Europe is a multilingual society with 24 official European Union Member State languages and dozens of additional languages including regional and minority languages. The only meaningful way to enable multilingualism and to benefit from this rich linguistic heritage is through Language Technologies (LT) including Natural Language Processing (NLP), Natural Language Understanding (NLU), Speech Technologies and language-centric Artificial Intelligence (AI) applications. The European Language Grid provides a single umbrella platform for the European LT commun...
Data-Intensive Workflow Management
Workflows may be defined as abstractions used to model the coherent flow of activities in the context of an in silico scientific experiment. They are employed in many domains of science such as bioinformatics, astronomy, and engineering. Such workflows usually present a considerable number of activities and activations (i.e., tasks associated with activities) and may need a long time for execution. Due to the continuous need to store and process data efficiently (making them data-intensive workflows), high-performance computing environments allied to parallelization techniques are used to run these workflows. At the beginning of the 2010s, cloud technologies emerged as a promising environmen...
Research in Computational Molecular Biology
This book constitutes the proceedings of the 22nd Annual Conference on Research in Computational Molecular Biology, RECOMB 2018, held in Paris, France, in April 2018. The 16 extended and 22 short abstracts presented were carefully reviewed and selected from 193 submissions. The short abstracts are included in the back matter of the volume. They report on original research in all areas of computational molecular biology and bioinformatics.
Digital Humanities Workshops
Digital Humanities Workshops is the first volume to focus explicitly on the most common and accessible kind of training in digital humanities (DH): workshops. Drawing together the experiences and expertise of dozens of scholars and practitioners from a variety of disciplines and geographical contexts, the chapters in this collection examine the development, deployment, and assessment of a workshop or workshop series. In the first section, "Where?", the authors seek to situate digital humanities workshops within local, regional, and national contexts. The second section, "Who?", guides readers through questions of audience in relation to digital humanities workshops. In the third and final section, "How?", authors explore the mechanics of such workshops. Taken together, the chapters in this volume answer the important question: why are digital humanities workshops so important and what is their present and future role? Digital Humanities Workshops examines a range of digital humanities workshops and highlights audiences, resources, and impact. This volume will appeal to academics, researchers and postgraduate students, as well as professionals working in the DH field.
The Origins of Genome Architecture
The availability of genomic blueprints for hundreds of species has led to a transformation in biology, encouraging the proliferation of adaptive arguments for the evolution of genomic features. This text explains why the details matter and presents a framework for how the architectural diversity of eukaryotic genomes and genes came to arise.
