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Crystals and Life
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Ligand Efficiency Indices for Drug Discovery
The purpose of Ligand Efficiency Indices for Drug Discovery: Towards an Atlas-Guided Paradigm is to introduce in a concise and self-contained form the concepts, ideas, applications and examples of efficiency-driven drug discovery to the biomedical community at large. The book emphasizes the use of 'new variables' and more objective numerical methods to drive drug discovery in an encompassing way. These 'new variables' are based on Ligand Efficiency Indices (LEIs) formulated in a way that permits mapping Chemico-Biological Space (CBS) in an Atlas-like representation. It provides a practical and timely discussion of the concepts, ideas, applications and examples of efficiency-driven drug disco...
Proceedings of 10th World Congress on Medicinal Chemistry & Drug Design 2018
June 14-15, 2018 Barcelona,Spain Key Topics : Medicinal Chemistry, Pharmaceutical Sciences, Drug Design and Drug Development, CADD (Computer Aided Drug Design), Bioorganic and Medicinal Chemistry, Pharmacology and toxicology, Anticancer agents in Medicinal Chemistry, Analytical Chemistry, Pharmaceutical Industry, Organic Chemistry, Clinical Pharmacology, Evolution of Organic and Medicinal Chemistry in Pharma, Organic and Medicinal Chemistry Technologies for Drug Discovery, QSAR (Quantitative Structure-Activity Relationship) Fragment-Based Drug Design, Applications of Organic and Medicinal Chemistry in Drug Discovery, Market Dynamics, Conclusions and Future Trends, Medicinal Plants,
The Black Box of Biology
In this masterful account, a historian of science surveys the molecular biology revolution, its origin and continuing impact. Since the 1930s, a molecular vision has been transforming biology. Michel Morange provides an incisive and overarching history of this transformation, from the early attempts to explain organisms by the structure of their chemical components, to the birth and consolidation of genetics, to the latest technologies and discoveries enabled by the new science of life. Morange revisits A History of Molecular Biology and offers new insights from the past twenty years into his analysis. The Black Box of Biology shows that what led to the incredible transformation of biology w...
Molecular Plant Virology
In calling this series Molecular Plant Virology, I had in mind aspects of plant virology of interest to biochemists, molecular geneticists, biophysicists, genetic engineers, or, collectively,molecular biologists. At the same time, the intention was to provide up-to-date reviews, by expert contributors, on current research topics in plant virology of interest and referential use to virologists and plant biologists. The selected topics are pitched mainly at a research level, but with sufficient introduction and cross-referencing to enable graduate students to enter this fascinating field and, hopefully, not get lost.
Caught By Viruses
The current book attempts to give a glimpse of the scientific life of Michael Rossmann. The book begins with his very interesting and moving autobiography. His enormous energy must have been evident already from early childhood when he and his mother had to emigrate from Nazi-Germany to England, via The Netherlands. Starting school with a new language was a challenge that he managed well with the assistance of understanding teachers. Crystallography soon became the tool to explore new worlds, unknown to everybody. With a skill for mathematics, he realized that the transform of a molecular structure in the diffraction pattern could be used for analysis of both symmetry and structural relation...
Collected Abstracts
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The Cancer Chronicles
When author's wife was diagnosed with a metastatic cancer, he plunged himself into a study of the disease and of the people who dedicate their lives to understanding and combating it. What he discovered is that a revolution is now underway - an explosion of theories about what cancer really is and where it comes from. This book tells his story.
