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Handbook of the Neuroscience of Aging
A single volume of 85 articles, the Handbook of the Neurobiology of Aging is an authoritative selection of relevant chapters from the Encyclopedia of Neuroscience, the most comprehensive source of neuroscience information assembled to date (AP Oct 2008). The study of neural aging is a central topic in neuroscience, neuropsychology and gerontology. Some well-known age-related neurological diseases include Parkinson's and Alzheimer's, but even more common are problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and slee...
Functional Neurobiology of Aging
Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided b...
Body Composition and Aging
Increased adiposity and decreased muscle mass contribute substantially to age-dependent disease and disability. In particular age-related increase in adiposity is quickly becoming a major threat to public health throughout the world. Although the hypothesis that age-related changes in body composition are due to lifestyle choices alone is well accepted, it is a vast oversimplification. This volume reflects the current knowledge in this rapidly developing field of research. The first part of the book discusses the extent to which increased adiposity contributes to age-related diseases and longevity. The 'obesity paradox', describing the protective role of overweight in decreasing mortality while increasing pathology, is covered in depth. Further chapters address specific aspects of the regulation of energy balance during aging, including the effects of changes in food intake. Finally the causes and consequences of loss of muscle mass and age-related osteoporosis are examined. A valuable help for physicians treating elderly patients, this book will also be of great interest to researchers studying energy balance, muscle physiology, bone disease, and other aspects of aging.
Functional Endocrinology of Aging
One of the most demanding aspects regarding the endocrinology of aging is to determine the extent to which hormones change with age, independent of age-related pathologies, and the clinical significance of these changes. The emphasis of the present volume is on function, as it is of particular interest to many nonspecialists under what circumstances endocrine therapy may be useful in the elderly. For this purpose, leading investigators in their respective fields review the most important hormonal systems affected by aging. Furthermore, to facilitate the utility of the reviews particularly for nonspecialists, the book emphasizes the critical analysis of specific issues: The extent to which th...
Mechanisms of Dietary Restriction in Aging and Disease
Dietary restriction uniquely and robustly increases maximum lifespan and greatly reduces age-related diseases in many species, including yeast, flies, nematodes, and mammals. To study mechanisms mediating the protective effects of dietary restriction, the National Institute of Aging convened a program involving several leading gerontological laboratories. Results from many of these, as well as from other leading research institutions in the field, are presented in this book. The first three papers address general molecular mechanisms, derived in part from recent DNA microarray studies, that may mediate protective effects of dietary restriction. The subsequent articles examine specific model systems, including flies, nematodes and non-human primates, that have provided exciting new information about these mechanisms. Finally, mechanisms of dietary restriction mediating protective effects against cancer and neurological diseases are discussed. In addition to gerontologists and geriatricians, many other medical and nonmedical professionals in the field will find a great wealth of information on possible interventions that may ameliorate age-related diseases.
Mechanisms of Dietary Restriction in Aging and Disease
Dietary restriction uniquely and robustly increases maximum lifespan and greatly reduces age-related diseases in many species, including yeast, flies, nematodes, and mammals. To study mechanisms mediating the protective effects of dietary restriction, the
Body Composition and Aging
Increased adiposity and decreased muscle mass contribute substantially to age-dependent disease and disability. In particular age-related increase in adiposity is quickly becoming a major threat to public health throughout the world. Although the hypothesis that age-related changes in body composition are due to lifestyle choices alone is well accepted, it is a vast oversimplification. This volume reflects the current knowledge in this rapidly developing field of research. The first part of the book discusses the extent to which increased adiposity contributes to age-related diseases and longevity. The 'obesity paradox', describing the protective role of overweight in decreasing mortality while increasing pathology, is covered in depth. Further chapters address specific aspects of the regulation of energy balance during aging, including the effects of changes in food intake. Finally the causes and consequences of loss of muscle mass and age-related osteoporosis are examined.A valuable help for physicians treating elderly patients, this book will also be of great interest to researchers studying energy balance, muscle physiology, bone disease, and other aspects of aging.
Current Topics in Membranes and Transport
Current Topics in Membranes and Transport
Neuroendocrinology of Aging
JOSEPH MEITES The idea that the endocrine system is involved in aging processes is as old as the beginnings of endocrinology. The first endocrine experiment related to aging was reported by Brown-Sequard, who is usually re garded as the "father of endocrinology. " In 1889, at the age of 72 years, he reported that he had succeeded in rejuvenating himself by injections of testicular extracts from dogs and guinea pigs. Although the favorable effects observed may have been due mainly to the powers of auto suggestion, his reports created a considerable interest in endocrinology and its relation to aging, and eventually led to the use of estrogens for treating certain pre-and postmenopausal sympto...
