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Chiral Building Blocks in Asymmetric Synthesis A comprehensive introduction to the important classes of chiral building blocks Chirality — the asymmetric quality found in certain chemical compounds — plays an essential role in our world: chiral compounds can be found in biology, pharmaceutical compounds, agrochemicals, and fragrances. The stereoselective preparation of these complex molecular constructions constitutes a challenge. To this end, modern asymmetric synthesis utilizes a variety of valuable and efficient reagents employed as chiral auxiliaries, metal complexes and organocatalysts in stereoselective catalysis, and enantiopure reactants termed as chiral building blocks. In Chira...
Selenium-based methods in synthetic chemistry have developed rapidly over the past years and are now offering highly useful tools for organic synthesis. Filling the gap for a comprehensive handbook and ready reference, this book covers all modern developments within the field, including biochemical aspects. The chemistry chapters are organized according to the different reactivities of various selenium compounds and reagents, with each chapter dealing with a special reaction type. Also includes a table with 77Se NMR shifts to aid in practical problems. From the Contents: * Electrophilic and Nucleophilic Selenium * Selenium Compounds in Radical Reactions * Selenium-Stabilized Carbanions * Selenium Compounds with Valency Higher than Two * Selenocarbonyls * Selenoxide Elimination and [2,3]-Sigmatropic Rearrangement * Selenium Compounds as Ligands and Catalysts * Biological and Biochemical Aspects of Selenium Compounds
The use of organoselenium reagents as catalysts is a common thread that runs through the chapters of this book, introducing important aspects of the modern organoselenium chemistry: organocatalysis, green chemistry, bioinspiration, antioxidant activity. The eBook covers the most recent developments in the classical synthetic application of organoselenium reagents such as electrophilic, nucleophilic and free radical reagents. The volume also features a discussion on the synthesis and the synthetic applications of some emerging classes of selenium compounds such as hypervalent selenium species and selenoamides, and also addresses some biological aspects such as the antimicrobial activity of organoselenium derivatives and the biochemistry of selenoproteins. A number of eminent scientists from different research groups were involved in the preparation of the 13 chapters of the book, making Organoselenium Chemistry: Between Synthesis and Biochemistry an excellent reference about selenium chemistry for researchers and graduate students in the field of selenium chemistry.
This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and therapeutic applications
Selenium and Tellurium Reagents provides an in-depth overview of recent advances on the chemistry of these elements. Written by internationally recognized experts, it gives insight into the synthesis, structure, analysis and mechanistic studies of these compounds. The book is organized into four parts which reflect the applications of Se and Te reagents in four areas: inorganic chemistry, organic chemistry, materials science and biochemistry.
The DK Eyewitness Rome Travel Guide will lead you straight to the best attractions Rome has to offer. The guide includes unique cutaways, floorplans and reconstructions of the city's stunning architecture, plus 3D aerial views of the key districts to explore on foot. You'll find detailed listings of the best hotels, restaurants, bars and shops for all budgets in this fully updated and expanded guide, plus insider tips on everything from where to find the best markets and nightspots to great attractions for children. The uniquely visual DK Eyewitness Travel Guide includes in-depth coverage of all the unforgettable sights. The DK Eyewitness Rome Travel Guide shows you what others only tell you. Now available in PDF format.
Selenium and Selenoproteins in Cancer, Volume 136, the latest release in the Advances in Cancer Research series, provides invaluable information on the fast-moving field of cancer research. This updated volume includes chapters on The epidemiology of selenium and human cancer, Selenium, epigenetics and cancer, Selenium status and cancer risk, Nutritional aspects of selenium and breast cancer risk: focus on cellular and molecular mechanisms, Selenoproteins in tumorigenesis and cancer progression, Selenoproteins and metastasis, The tumor microenvironment and inflammatory factors, and Selenium-dependent glutathione peroxidases during tumor development. This new release in the series presents original reviews on research regarding the prevention and treatment of cancer with selenium. - Provides information on cancer research and prevention - Offers outstanding and original reviews on a range of cancer research topics, with this volume focusing on the role of selenium and selenoproteins in cancer prevention - Serves as an indispensable reference for researchers and students alike
DK Eyewitness Italy travel guide will lead you straight to the best attractions Italy's kaleidoscope of regions have on offer. Packed with photographs and illustrations the guide explores every facet that makes the country irresistable; from the Alps in the far north to the sun-blessed Mediterranean shores of the south. The guide provides all the insider tips every visitor needs from soaking up the romance of Verona, basking in the warm evening sun in Tuscany, or gaping at the ancient ruins lining the streets of Rome as well as comprehensive listings of the best hotels, villas, resorts, restaurants, and nightlife in each region for all budgets. You'll find 3D cutaways and floorplans of all the must-see sites. DK Eyewitness Italy explores the history, classical origins, architecture and art of this stylish and charismatic country - and still finds room to recommend a wine to go with the risi e bisi or the maccheroni con le sarde. With up-to-date information on getting around by train, boat, car, walking in cities and all the sights, beaches, and resorts listed town by town, DK Eyewitness Italy is indispensable. Don't miss a thing on your holiday with the DK Eyewitness Italy