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Assessing the Reliability of Complex Models
Advances in computing hardware and algorithms have dramatically improved the ability to simulate complex processes computationally. Today's simulation capabilities offer the prospect of addressing questions that in the past could be addressed only by resource-intensive experimentation, if at all. Assessing the Reliability of Complex Models recognizes the ubiquity of uncertainty in computational estimates of reality and the necessity for its quantification. As computational science and engineering have matured, the process of quantifying or bounding uncertainties in a computational estimate of a physical quality of interest has evolved into a small set of interdependent tasks: verification, v...
Algorithms and Complexity in Mathematics, Epistemology, and Science
ACMES (Algorithms and Complexity in Mathematics, Epistemology, and Science) is a multidisciplinary conference series that focuses on epistemological and mathematical issues relating to computation in modern science. This volume includes a selection of papers presented at the 2015 and 2016 conferences held at Western University that provide an interdisciplinary outlook on modern applied mathematics that draws from theory and practice, and situates it in proper context. These papers come from leading mathematicians, computational scientists, and philosophers of science, and cover a broad collection of mathematical and philosophical topics, including numerical analysis and its underlying philos...
The Mechanics of Jointed Structures
This book introduces the challenges inherent in jointed structures and guides researchers to the still-open, pressing challenges that need to be solved to advance this critical field. The authors cover multiple facets of interfacial mechanics that pertain to jointed structures: tribological modeling and measurements of the interface surfaces, constitutive modeling of joints, numerical reduction techniques for structures with joints, and uncertainty quantification and propagation for these structures. Thus, the key subspecialties addressed are model reduction for nonlinear systems, uncertainty quantification, constitutive modeling of joints, and measurements of interfacial mechanics propertie...
Principles of Big Data
Principles of Big Data helps readers avoid the common mistakes that endanger all Big Data projects. By stressing simple, fundamental concepts, this book teaches readers how to organize large volumes of complex data, and how to achieve data permanence when the content of the data is constantly changing. General methods for data verification and validation, as specifically applied to Big Data resources, are stressed throughout the book. The book demonstrates how adept analysts can find relationships among data objects held in disparate Big Data resources, when the data objects are endowed with semantic support (i.e., organized in classes of uniquely identified data objects). Readers will learn...
Benzel's Spine Surgery
Written and edited by world-renowned experts in the field, Benzel’s Spine Surgery: Techniques, Complication Avoidance and Management, 5th Edition, provides expert, step-by-step guidance on the evaluation and management of disorders of the spine. This definitive, two-volume work explores the full spectrum of techniques used in spine surgery, giving you the tools you need to hone your skills and increase your knowledge in this challenging area. Clearly organized and extensively revised throughout, it features contributions from both neurosurgeons and orthopaedic surgeons to present a truly comprehensive approach to spine disease. Offers a thorough overview of the effective management of pati...
Informatics for Materials Science and Engineering
Materials informatics: a ‘hot topic’ area in materials science, aims to combine traditionally bio-led informatics with computational methodologies, supporting more efficient research by identifying strategies for time- and cost-effective analysis. The discovery and maturation of new materials has been outpaced by the thicket of data created by new combinatorial and high throughput analytical techniques. The elaboration of this "quantitative avalanche"—and the resulting complex, multi-factor analyses required to understand it—means that interest, investment, and research are revisiting informatics approaches as a solution. This work, from Krishna Rajan, the leading expert of the infor...
Precision Medicine and the Reinvention of Human Disease
Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinic...
Research Challenges in Modeling and Simulation for Engineering Complex Systems
This illuminating text/reference presents a review of the key aspects of the modeling and simulation (M&S) life cycle, and examines the challenges of M&S in different application areas. The authoritative work offers valuable perspectives on the future of research in M&S, and its role in engineering complex systems. Topics and features: reviews the challenges of M&S for urban infrastructure, healthcare delivery, automated vehicle manufacturing, deep space missions, and acquisitions enterprise; outlines research issues relating to conceptual modeling, covering the development of explicit and unambiguous models, communication and decision-making, and architecture and services; considers key com...
From Maps to Models
The United States faces numerous, varied, and evolving threats to national security, including terrorism, scarcity and disruption of food and water supplies, extreme weather events, and regional conflicts around the world. Effectively managing these threats requires intelligence that not only assesses what is happening now, but that also anticipates potential future threats. The National Geospatial-Intelligence Agency (NGA) is responsible for providing geospatial intelligence on other countriesâ€"assessing where exactly something is, what it is, and why it is importantâ€"in support of national security, disaster response, and humanitarian assistance. NGA's approach today relies heavily...
