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Cystogenesis
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secreti...
Cross-cultural Issues in Bioethics
Human cloning is a main focus of current bioethical discussion. Involving the self-understanding of the human species, it has become one of the most debated topics in biomedical ethics, not only on the national, but also on the international level. This book brings together articles by bioethicists from several countries who address questions of human cloning within the context of different cultural, religious and regional settings against the background of globalizing biotechnology. It explores on a cross-cultural level the problems and opportunities of global bioethics.
Pathogenesis and Treatment in IgA Nephropathy
This book discusses the latest findings on the pathogenesis and treatment of IgA nephropathy. It particularly focuses on recently recognized initiation and progression factors and the varying treatment strategies in different regions, such as Asia, Europe, and the United States. More than 40 years have passed since Dr. Jean Berger first described primary IgA nephropathy (“Nephropathy with mesangial IgA-IgG deposits”) as a new disease entity. Immunohistopathologically, IgA nephropathy is characterized by the granular deposition of IgA (IgA1) and C3 in the glomerular mesangial areas with mesangial cell proliferation and the expansion of mesangial matrices. It is clear that IgA nephropathy ...
The Stem Cell Hope
A landmark book by the senior science writer at Time magazine introduces us to a medical breakthrough that can save our lives. Few people know much about stem cell research beyond the ethical questions raised by using embryos. But in the last decade, stem cell research has made huge advances toward eliminating some of our most intractable diseases. Now this sweeping and accessible book introduces us to this cutting-edge science that will revolutionize medicine and change the way we think about and treat disease. Alice Park takes us from stem cell's controversial beginnings to the recent electrifying promise of being able to create the versatile cells without using embryos at all. She shows us how stem cells give researchers an unprecedented ability to study disease while giving patients the promise of replacing diseased cells with healthy new ones. And she profiles the scientists and leaders-many with their own compelling stories-who have fueled the quest and will continue to shape the field in years to come.
The Body Divided
Bodies and body parts of the dead have long been considered valuable material for use in medical science. Over time and in different places, they have been dissected, autopsied, investigated, harvested for research and therapeutic purposes, collected to turn into museum and other specimens, and then displayed, disposed of, and exchanged. This book examines the history of such activities, from the early nineteenth century through to the present, as they took place in hospitals, universities, workhouses, asylums and museums in England, Australia and elsewhere. Through a series of case studies, the volume reveals the changing scientific, economic and emotional value of corpses and their contested place in medical science.
Science and Public Policy
Argues that the virtual nature of much environmental science and the application of non-science principles such as the precautionary principle facilitate the virtuous corruption of environmental science. This book illustrates that the problem is widespread than this area alone would suggest and is common in the important field of climate science.
