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Dr. Levy has secured the field’s top experts to offer the latest clinical reviews on cholestatic liver disease. The issue will include articles devoted to The Gut-Liver Axis; Update on Genetics in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis; New thoughts on IgG4 Associated Cholangitis; Cancer Risk and Surveillance in PSC; Novel Therapies for PBC; and Liver transplantation for Cholestatic Liver Diseases, to name a few. Dr. Levy’s issue will be the most current authority on cholestatic liver disease.
The Guest Editors have put together an issue of clinical reviews that provides the most current look at PBC. Authors, all experts in their respective areas, have submitted articles in the following areas: Changes in epidemiology of PBC; Genetic and epigenetics in PBC; Role of bile acids and the bicarbonate umbrella in the pathogenesis of PBC; Current treatment options in PBC; Work in progress: Drugs in development; Natural history of PBC in the UDCA era: Role of scoring systems; Treatment of Pruritus: Tricks of the trade; Chronic complications of cholestasis: Work-up and Management; Individualizing care: Management beyond medical therapy; Role of liver biopsy: When to do, how to stage; AMA-negative PBC: Is it really the same as AMA-positive PBC?; New thoughts on Overlap syndrome with auto-immune hepatitis; and Current status of liver transplantation for PBC.
Over the past two decades, there has been a steady increase in knowledge associated with the clinical manifestations of cholestatic liver disease. Based on these clinical situations, this book provides useful and timely information on the ever-expanding subject of cholestatic liver disease. It supplies scientific updates from leading experts which relate to the clinical evaluation and management of cholestatic liver disorders.
After serving a prison sentence for bigamy and cashiered from the army, Will Crosby quits England for life as a sergeant in the Queensland constabulary, hoping to regain lost self-esteem and the forgiveness of his wronged ‘wife’, Alice. A typhus epidemic on board ship puts his plans in jeopardy as the vessel and its occupants must spend an indefinite time at the ill-prepared quarantine station on Stradbroke Island. The new, unpredictable relationships Will establishes, especially with Thomas, a lapsed Irish Catholic priest, and Billy, a newly orphaned six-year old, together with his experiences and responsibilities on Stradbroke, project his life in hitherto unimagined directions. The to...
Meet 85-year old Dr Abby Waterman, the unwelcome third daughter of Orthodox Jews who desperately wanted a son. She survives rat-infested cold-water tenements in London's East End, the Great Depression, WW2 and the Blitz. Despite poverty, sexual harassment and discrimination, she becomes in turn a Harley Street dentist, a doctor, an entrepreneur, a consultant pathologist and director of a cancer research laboratory, as well as the mother of four. Behind the scenes in a busy NHS hospital, you witness the tears doctors shed that patients never see. Step into Abby's shoes as an 18-year-old dissecting her first body and later, as a mother of young children, carrying out an autopsy on a four-year-old. She undergoes treatment for breast cancer, only to be told her cancer has spread to her spine. While on a ventilator following a heart attack, she learns that Do Not Resuscitate is written into her notes. 'Woman in a White Coat' was short-listed for the Tony Lothian Biography Prize and the Wasafiri Memoir Prize
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Dr. Levy is a key leader in the field of hepatology , and she has enlisted authors who are top experts in their fields to submit state-of-the-art clinical reviews on cholestatic liver diseases. Articles are devoted to genetic determinants of cholestasis, nuclear receptors as drug targets, drug-induced cholestasis, primary sclerosing cholangitis, therapeutic advances in primary biliary cirrhosis, overlap syndromes, autoimmune sclerosing cholangitis, secondary sclerosing cholangitis, Focus is also on familial cholestasis, allagile syndrome and other hereditary causes of cholestasis, Systemic causes of cholestasis, advances in pathogenesis and treatment of pruritus, care of the cholestatic patient, and transplantation for cholestatic diseases . Readers will come away with a full overview of the diagnosis and treatment of cholestatic liver diseases.
Assessing Haydn's quartets, this work explores the circumstances of their creation. It reveals the conventions and novelties that govern their design and examines the wealth of textures stylistic allusions, and rhetorical strategies that underlie their stature as a cornerstone of the chamber music repertory.
In this issue of Clinics in Liver Disease, guest editor Dr. John V. Binu brings his considerable expertise to the topic of Primary Biliary Cholangitis. PBC leads to inflammation and scarring of the small bile ducts, and, if untreated, can lead to cirrhosis and liver failure. In this issue, top experts provide a state-of-the-art review of diagnosis and treatment for this chronic, progressive liver disorder. - Contains 13 practice-oriented topics including genetics of primary biliary cholangitis; prognostic scoring systems in PBC; overlap syndromes and PBC; non-invasive evaluation of fibrosis and portal hypertension in PBC; treatment of PBC: first- and second-line therapies; novel therapies for PBC; and more. - Provides in-depth clinical reviews on primary biliary cholangitis, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Dr. Adrian Reuben updates one of the most highly requested topics in liver disease by inviting highly distinguished authors to address the important aspects of diagnosis and treatment of hepatocelluar carcinoma. State-of-the-art issues are addressed, including the role of oncogenic viruses, molecular and genetic guidelines, and screening and staging. Dr. Reuben, himself, concludes the issue with an important article on an agorithmic approach to diagnosis and treatment: Resect, Ablate, Replace or Intoxicate?