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Bálint’s syndrome is named after the Hungarian physician who first reported a remarkable case of a man with complex visuospatial deficits following bilateral lesions within parietal and occipital cortex (Bálint, 1909). The syndrome has three primary symptoms: simultanagnosia (impaired spatial awareness of more than one object at time), optic ataxia (misreaching to visual targets) and ocular apraxia (described by Bálint as “psychic paralysis of gaze”). Balint’s patients not only cannot perceive more than one object at time and therefore show poor comprehension of multi-object visual scenes i.e. poor detection of all the objects present and difficulty in grasping the relationship be...
T-cells are an essential component of the immune system that provide protection against pathogen infections and cancer and are involved in the aetiology of numerous autoimmune and autoinflammatory pathologies. Their importance in disease, the relative ease to isolate, expand and manipulate them ex vivo have put T-cells at the forefront of basic and translational research in immunology. Decades of study have shed some light on the unique way T-cells integrate extrinsic environmental cues influencing an activation program triggered by interactions between peptide-MHC complexes and the antigen-recognition machinery constituted of clonally distributed T-cell receptors and their co-receptor CD4 o...
This volume presents the major outcome of the IUTAM symposium on “Advanced Materials Modeling for Structures”. It discusses advances in high temperature materials research, and also to provides a discussion the new horizon of this fundamental field of applied mechanics. The topics cover a large domain of research but place a particular emphasis on multiscale approaches at several length scales applied to non linear and heterogeneous materials. Discussions of new approaches are emphasised from various related disciplines, including metal physics, micromechanics, mathematical and computational mechanics.
Engineering mechanics involves the development of mathematical models of the physical world. Statics addresses the forces acting on and in mechanical objects and systems. Statics with MATLAB® develops an understanding of the mechanical behavior of complex engineering structures and components using MATLAB® to execute numerical calculations and to facilitate analytical calculations. MATLAB® is presented and introduced as a highly convenient tool to solve problems for theory and applications in statics. Included are example problems to demonstrate the MATLAB® syntax and to also introduce specific functions dealing with statics. These explanations are reinforced through figures generated with MATLAB® and the extra material available online which includes the special functions described. This detailed introduction and application of MATLAB® to the field of statics makes Statics with MATLAB® a useful tool for instruction as well as self study, highlighting the use of symbolic MATLAB® for both theory and applications to find analytical and numerical solutions
In oncology today the accent lies on a multi-disciplinary approach, and consequently this handbook aims to provide wide-ranging information regarding all aspects of the surgical treatment of cancer. It deals with the basic subjects: the biology of cancer, detection and diagnosis, and treatment concepts. From screening to the application of markers, from new transplantation techniques to psychological aspects, an overall picture is presented. The surgeon will find chapters to enhance his knowledge of those areas which may not have required his attention until now. This volume should serve as a valuable reference for many years to come.
**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Pediatrics**Covering every aspect of general pediatric practice, as well as details for many pediatric subspecialists, Nelson Textbook of Pediatrics, 22nd Edition, brings you fully up to date with everything from rapidly changing diagnostic and treatment protocols to new technologies to the wide range of biologic, psychologic, and social problems faced by children today. Edited and written by experts and prominent members of the pediatric medical community, this comprehensive two-volume reference covers both the science and art of pediatric practice. It remains the reference of choice among pediatricians, pedi...
The World Stroke Organization reports that “stroke has already reached epidemic proportions. Globally1 in 4 adults over the age of 25 will have a stroke in their lifetime. 12.2 million people worldwide will have their first stroke this year, and 6.5 million will die as a result.” Ischemic strokes are the most common type of stroke, with about 87% of all strokes being ischemic strokes. This new volume addresses this epidemic by presenting detailed studies on ischemic injury, with emphasis on the molecular-level mechanisms and the role of signaling pathways in the body, their structure, and their mechanism of action. The book focuses on molecular pharmacology plans and explains the new are...
"Doctors reading this book will not only be convinced of the need for medical supervison (for all doctors - even pathologists and coroners); they will also be given a handy smorgasbord of different types of medical supervision from which to choose ... There may not be many ways of rekindling the spark of compassion and loving kindness that made us want to become health professionals at the start of our careers, but Owen and Shohet have demonstrated that empathic supervision, whether this is from fellow professionals or from peers, is certainly one way of achieving this." Brian Kaplan, MD With a foreword by Iona Heath, President of the Royal College of General Practitioners. This book helps t...