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Progress in Drug Research 56
Founded in 1959 by its current Editor, the series has moved from its initial focus on medicinal chemistry to a much wider scope. Today it encompasses all fields concerned with the development of new therapeutic drugs and the elucidation of their mechanisms of action, reflecting the increasingly complex nature of modern drug research. Invited authors present their biological, chemical, biochemical, physiological, immunological, pharmaceutical, toxicological, pharmacological and clinical expertise in carefully written reviews and provide the newcomer and the specialist alike with an up-to-date comprehensive list of prime references. Each volume of Progress in Drug Research contains fully cross-referencing indices which link the books together, forming a virtually encyclopaedic work. The series thus serves as an important, time-saving source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines.
Progress in Medicinal Chemistry
Progress in Medicinal Chemistry
The Pyrimidines
The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.
Privileged Structures in Drug Discovery
A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book...
Calcium Channel Pharmacology
Voltage-gated calcium channels are critical regulators of cytoplasmic levels of calcium, the universal signaling ion. As such, calcium channels trigger a wide range of cellular functions, from muscle contraction to neurotransmitter secretion, and are important players in human disease. Prominent in the nervous, cardiovascular, and endocrine systems, members of the calcium channel family are targets for existing antihypertensive and anticonvulsant drugs. In addition, they are emerging targets for drugs to treat an extraordinarily diverse group of disorders, including pain, cerebral ischemia, cardiac arrhythmia, and migraine. This book reviews the compounds that target individual calcium channel subtypes and the cellular and behavioral functions governed by each different channel. It contains information for basic scientists using calcium channel antagonists as experimental tools, for behavioralists studying animal models of human disease, and for pharmaceutical scientists interested in creating the next generation of calcium channel-targeted drugs. Several factors make an entire book on calcium channel pharmacology timely.
Annual Reports in Medicinal Chemistry
Annual Reports in Medicinal Chemistry
Perspectives in Receptor Research
Perspectives in Receptor Research
Calcium Channels
The most comprehensive compendium of information available on calcium channels Calcium channels are a common component of the membranes of a wide range of excitable cells, and their presence is crucial to the functioning of these cells. This book presents a current review of the biophysics, physiology, pharmacology, and clinical role of calcium channels. Chapters discussing the biophysics of calcium channels include topics in ion permeation, channel activation, channel inactivation, and second messenger modulation. The chapters on physiology cover excitation-contraction coupling, excitation-secretion coupling, sensory transduction, regulation of electrical activity, and the regulation of cel...
Molecular Structures and Dimensions
This volume is the fourteenth classified bibliography of organic, organometallic and metal complex crystal structures prepared by the Cambridge Crystallo graphic Data Centre and published jointly with the International Union of Crystallography. The previous thirteen volumes covered the years 1935-81; the majority of references in the present volume pertain to structure analyses reported in the literature during 1981 and 1982. A few structures reported prior to 1981 and omitted in earlier volumes are also included. Volume 14 contains 4094 references to 4001 distinct chemical compounds with 2162 cross-references. Some 90% of these references were obtained by direct in-house scanning of 51 majo...
