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Nuclear Transport
Both from a morphological and a functional point of view, the nucleus is central to modern cell biology. Transport of proteins and RNAs between the nucleus and the cytoplasm continues to be a fascinating research topic on its own. Furthermore, it affects many aspects of gene expression and general cellular functions and has far-reaching implications for human health. In this book, we cover a wide range of topics from the nuclear transport field. Individual chapters deal with the general concepts of nucleocytoplasmic transport, with various transport pathways like nuclear protein import, mRNA export and tRNA trafficking, and with the molecular mechanisms that govern macromolecular exchange between the two compartments. Others address new technologies that will help to answer open questions in the future. Together, we hope to provide a collection of reviews that should be useful for experts in the field, as well as for a wider audience.
Viral Interactions with the Nucleus
Viruses cause numerous medically important diseases, affecting developing, developed, rich and poor alike. The diseases vary in severity, including chickenpox, smallpox, influenza, shingles, herpes, rabies, polio, Ebola, hanta fever, AIDS and the common cold, amongst others. Regardless of the type of tissue or organ affected, all viruses follow the same basic steps to infect host cells. Once in contact with host cells viruses release their genetic material into the cell followed by genome replication, production of viral proteins, assembly of the virus particle and egress from the infected cell. Viruses disrupt normal host cell processes in order to facilitate their own replication/assembly ...
Cancer Research
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Radicals and Reformers
With Bibles and baptism, a movement was born. From renegade gatherings of Christian believers in the 1500s to a global communion of more than 2.1 million members, the Anabaptist-Mennonite movement has been marked by faithfulness and failure, continuity and conflict, radicalism and reformation. In this engaging history, Radicals and Reformers traces the origins and development of the Anabaptist and Mennonite movements from their beginnings in Europe through their spread across the globe. In this new authoritative introduction to Anabaptist history, historian Troy Osborne reflects on the ways that Anabaptists have defined their identity in new settings and in response to new theological, intellectual, geographic, and political contexts. Drawing from current scholarship and a range of written and visual sources, this book provides an overview of how Mennonites from Zurich to Zimbabwe have adapted to or resisted the world around them.
The Great American Outlaw
This book explores in depth the origins, development, and prospects of outlawry and of the relationship of outlaws to the social conditions of changing times. Throughout American history you will find larger-than-life brigands in every period and every region. Often, because we hunger for simple justice, we romanticize them to the point of being unable to separate fact from fiction. Frank Richard Prassel brings this home in a thorough and fascinating examination of the concept of outlawry from Robin Hood, Dick Turpin, and Blackbeard through Jean Lafitte, Pancho Villa, and Billy the Kid to more modern personalities such as John Dillinger, Claude Dallas, and D. B. Cooper. A separate chapter on...
On the Air
Now long out of print, John Dunning's Tune in Yesterday was the definitive one-volume reference on old-time radio broadcasting. Now, in On the Air, Dunning has completely rethought this classic work, reorganizing the material and doubling its coverage, to provide a richer and more informative account of radio's golden age. Here are some 1,500 radio shows presented in alphabetical order. The great programs of the '30s, '40s, and '50s are all here--Amos 'n' Andy, Fibber McGee and Molly, The Lone Ranger, Major Bowes' Original Amateur Hour, and The March of Time, to name only a few. For each, Dunning provides a complete broadcast history, with the timeslot, the network, and the name of the show'...
Annetje Jans
Annetje Jans was accused of lifting her skirt while crossing a street, causing a flurry of gossip in Early New York. Settlers struggled to make a new world, but gossip and in-fighting was as much a part of New Amsterdam as was fighting the Indians. This is a concise history of Annetje Jans, also known as Anneke Janse, Anna Weber, Anna Webber, Anneke Webber, Anna Jane Webber, Annetje Bogartus, one of the first New York settlers. This 15th Century American Woman Colonist of New Amsterdam is ancestor to many, many thousands of Americans. This book contains information about many other New Amsterdam people as well.
