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Lupus is a disorder in which the body's immune system attacks itself, culminating in disease which can affect multiple organs, including the skin, joints, heart, lungs, kidneys, and central nervous system. Lupus currently affects about 30,000 patients in the UK, 500,000 in the United States and tens of thousands throughout Europe. Whilst there have been great advances in research into the genetic background of lupus and new interventions such as stem-cell transplants, there is still a surprising lack of information available for patients, carers and their families. Written by the former President of the British Society for Rheumatology and the current co-director of the Lupus Centre of Excellence in Pittsburgh, USA, this new edition of Lupus: The Facts reflects major developments in our understanding of the causes of lupus.
A strong clinical emphasis is present throughout this volume, from the first section of commonly presenting problems through to the section addressing problems shared with a range of other clinical sub-specialties.
Natural Autoantibodies provides an in-depth analysis of all aspects of natural antibodies. The book examines the advantages and pitfalls of every type of technique that is widely used for detecting autoantibodies. It also covers the sequencing of human autoantibody genes, discussing how sequencing is undertaken and the genetic clues available to elucidate the genetic origins of autoimmunity. Animal models of autoimmunity are also covered, and the up-to-date account provided in this book explains how natural autoantibodies have important regulatory functions and also occasionally serve as templates for autoimmunity. Other topics examined in Natural Autoantibodies: Their Physiological Role and Regulatory Significance include idiotypes of natural autoantibodies; the pathogenic role of natural autoantibodies; and methods to measure the effects of genetic and sex hormones, as well as aging, on natural autoantibodies. The book will be an excellent research tool and reference for immunologists, rheumatologists, and others interested in the topic.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Presenting the views of world experts on the causes and treatment of kidney diseases that complicate various rheumatologic diseases, this book includes pathogenesis, clinical features and treatment of diseases providing a readily accessible source of clinical advice for day-to-day practice.
Immunology, 8th Edition makes it easy for you to learn all the basic and clinical concepts you need to know for your courses and USMLEs. This medical textbook's highly visual, carefully structured approach makes immunology simple to understand and remember. Understand the building blocks of the immune system - cells, organs and major receptor molecules - as well as initiation and actions of the immune response, especially in a clinical context. Visually grasp and retain difficult concepts easily thanks to a user-friendly color-coded format, key concept boxes, explanatory diagrams, and over 190 photos to help you visualize tissues and diseases. Put concepts into practice. "Critical Thinking B...