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Anticancer Agents from Natural Products, Second Edition
The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well ...
Anticancer Agents from Natural Products
Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen
Inference Activities
The Inference Activities workbook is an easy to use manual that has been designed to engage your students with high interest scenarios. Each scenario contains several questions which prompt your students' thinking and problem solving abilities. This inferencing activities book focuses on teaching students inference and thinking skills. The book has over 100 compelling fiction and non-fiction scenarios to explore. After reading a scenario, students are prompted to look beyond surface details in the text and find the concealed meaning. This requires students to use their inferencing ability, an essential reading comprehension skill. The activities feature six sections: Section 1: Inference from Pictures and Text Section 2: Sentence level Inference Section 3: Paragraph level Inference (Non-fiction) Section 4: Paragraph Level Inference (Fiction) Section 5: Text Level Inference (Non-fiction) Section 6: Text Level Inference (Fiction) For school students ages 8-12.
Chemical Biology of Natural Products
Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.
Ethnomedicine and Drug Discovery
The emergence of new infectious, chronic and drug resistant diseases have prompted scientists to look towards medicinal plants as agents for treatment and prevention. This book provides an interphase between ethnomedical and ethnobotanical approaches to new drug discovery and advances in biotechnology and molecular science that has made it increasingly feasible to transform traditional medicines into modern drugs. These novel approaches also raise new issues and the volume explores economic, ethical and policy considerations of drug development based on indigenous knowledge or traditional medicine. This work also features standardization and development of phytomedicines for major therapeutic indications, including emerging infectious diseases affecting developing and developed countries. The publication provides state-of-the-art information on the most innovative science, the research, the industry, the market, and the future of ethnomedicine and drug discovery.
Natural Products
A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Hebrew and Hellene in Victorian England
Hebrew and Hellene explores the intellectual and personal relations among John Henry Newman, Matthew Arnold, and Walter Pater, three figures important in the development of nineteenth-century English thought and culture. Fundamentally concerned with the humanistic vision of Arnold and Pater, especially as they adapted the traditional religious culture to the needs of their generation, David DeLaura also recognizes Newman's central role. To a far greater degree than has been realized, Newman assumed a commanding position in the thought of the two younger men. DeLaura seeks to define the mechanics of the process by which the conservative religious humanism of Newman could be exploited in the f...
Grasslands and Climate Change
A comprehensive assessment of the effects of climate change on global grasslands and the mitigating role that ecologists can play.
Bioactive Compounds from Extremophiles
This SpringerBrief sheds new light on bioactive materials from extremophiles with the focus on the biosynthesis processes and related genomics. It deals with all aspects of the chemical compounds produced by organisms living under extreme conditions that may have potential as drugs or lead to novel drugs for human use.
Sociology
This carefully edited companion anthology provides provocative, eye-opening examples of the practice of sociology in a well-edited, well-designed, and affordable format. It includes short articles, chapters, and excerpts that examine common everyday experiences, important social issues, or distinct historical events that illustrate the relationship between the individual and society. The new edition will provide more detail regarding the theory and/or history related to each issue presented. The revision will also include more coverage of global issues and world religions.
