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Natural Products Targeting Clinically Relevant Enzymes
The past decade has seen the reappearance of natural products as a valuable source of potent therapeutics. Here, experts on bioactive natural products cover the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
The Odd, the Unusual, and the Strange
Abnormal burial practices have long been a source of fascination and debate within the fields of mortuary archaeology and bioarchaeology. The Odd, the Unusual, and the Strange investigates an unparalleled geographic and temporal range of burials that differ from the usual customs of their broader societies, emphasizing the importance of a holistic, context-driven approach to these intriguing cases. From an Andean burial dating to 3500 BC to mummified bodies interred in the Capuchin Catacombs of Palermo, Sicily, during the twentieth century, the studies in this volume cross the globe and span millennia. The unusual cases explored here include Native American cemeteries in Illinois, “vampire...
Phytochemistry Research Progress
This book is dedicated to new and important research in the field of phytochemistry which is in the strict sense of the word the study of phytochemicals. These are chemicals derived from plants. In a narrower sense the terms are often used to describe the large number of secondary metabolic compounds found in plants. Many of these are known to provide protection against insect attacks and plant diseases. They also exhibit a number of protective functions for human consumers. Techniques commonly used in the field of phytochemistry are extraction, isolation and structural elucidation (MS,1Dand 2D NMR) of natural products, as well as various chromatography techniques (MPLC, HPLC, LC-MS).
Studies in Natural Products Chemistry
Marine organisms have been increasingly regarded as excellent sources of new drugs for human therapeutics due to their remarkable chemistry, which, in turn, is reflected in their wide range of biological applications, including cancer, inflammation, infection, and pain. In the past 20 years, several new drugs have been discovered, some of them with novel pharmacological targets and the first sea-derived approved medicines are now paving their way into the market. In this chapter, we will focus on small-molecule drugs obtained from marine animals (sponges, gorgonians, mollusks, echinoderms) for the treatment of inflammation. The distribution of these compounds by different taxonomical families will be discussed, as well as the state-of-the-art regarding their structure–activity relationship. The most important chemical classes will be presented, such as terpenes, alkaloids, among others. The most important molecular targets, including phospholipase A2 (PLA2), cyclooxygenases (COXs), nitric oxide synthase (NOS), and NF-κB will be discussed.
OMICS
A reflection of the explosion of research and development in this field, OMICS: Biomedical Perspectives and Applications explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. A select editorial panel of experts discusses their cutting edge omics research and novel technologies, supplying a basic platform of methods and applications and a resource for enhanced cross-pollination in a multiomics approach to future endeavors in the fertile fields of omics research. After an introduction on the omics universe, the book presents modern omics and its applications in nanotechnology, genomics, proteomics,...
Studies in Natural Products Chemistry
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products. - Describes the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - A valuable resource for natural products and medicinal chemistry
Augustine of Hippo and Martin Luther on Original Sin and Justification of the Sinner
Pereira demonstrates how Augustine came to break with the patristic soteriology and anthropological theology and adopted the radicalism of grace with which he faced the theologians associated with the fifth-century Pelagianis. It was precisely that radicalism of grace that made of Augustine Luther's favourite theologian. The same radicalism was adopted by Luther in his opposition to the recentiores doctores, the Nominalist theologians. Without overlooking the crucial role played by the Pauline corpus, the author says that Augustine's anti-Pelagian thesis were at the core of the young Luther's soteriological and anthropological claims and were the driving force behind Luther's cry for reformation.
Blacks, Indians, and Spaniards in the Eastern Andes
During the seventeenth and eighteenth centuries, Mizque was a dynamic frontier region and the author shows that the Mizque frontier was a vibrant trade, transport, and communications link in the Andean highland-lowland axis.
