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Fibronectin
Fibronectin presents the studies made on the physiological and pathophysiological roles of fibronectin. The book presents chapters that discuss the primary structure of fibronectin and its mRNA; the physicochemical properties of fibronectin and fibronectin fragments; the fibronectin-containing extracellular matrix; the relationship of fibronectin and fibronectin-containing matrix to embryogenesis, wound healing, and the biology of cancer cells; the roles of fibronectin in platelet aggregation, attachment of microorganisms, pathogenesis of kidney diseases, arthritis, and lung fibrosis; and the production of purified concentrates of fibronectin suitable for use in patients. The book will be of much interest to biologists, biochemists, pharmacologists, and medical practitioners and researchers.
NIH Publication
None
Platelet Membrane Glycoproteins
It was just about ten years ago that platelet membrane glycoproteins were first charac terized and their abnormalities in congenital bleeding disorders first recognized. Dur ing this decade there has been a remarkable growth in our understanding of the structure and membrane organization of the platelet surface glycoproteins, their in teractions with external ligands during the process of hemostasis, and their defects causing hemorrhagic disease. These studies have advanced the knowledge of platelet involvement in hemostasis from a cellular to a molecular level, and they have provided a model for contact interactions among other cell types. This seemed a proper time to ask those who contribu...
Peterson's Graduate Programs in Pathology & Pathobiology; Pharmacology & Toxicology; Physiology; and Zoology
Peterson's Graduate Programs in Pathology & Pathobiology; Pharmacology & Toxicology; Physiology; and Zoology contains a wealth of information on universities that offer graduate/professional degrees in these fields that include Molecular Pathogenesis, Molecular Pathology, Molecular Pharmacology, Molecular Toxicology, Cardiovascular Sciences, Molecular Physiology, and Animal Behavior. Up-to-date data, collected through Peterson's Annual Survey of Graduate and Professional Institutions, provides valuable information on degree offerings, professional accreditation, jointly offered degrees, part-time and evening/weekend programs, postbaccalaureate distance degrees, faculty, students, degree requ...
Biology of Endothelial Cells
The participation of endothelial cells in various physiologic and pathologic processes has been hypothesized since before the turn of the century. However, until recently, direct evidence for endothelial involvement in these processes has been extremely difficult to obtain due to the inability to study endothelial cell function in vitro. Though the possibility of using cultured endothelial cells to study endothelial cell function in vitro was recognized many years ago, the inability to culture unambiguously identifiable endothelial cells limited investigators in their studies of endothelial function. As a result, the field of endothelial cell biology lay relatively fallow for many years. The...
Thrombospondin
Thrombospondin represents the most extensive compilation of knowledge on this important protein. Leading scientists from around the world cover such topics as the structure of the protein; its sequence and homologies with other proteins; its chemistry; and its involvement in protein interactions, cell interactions, and systemic functions. The book discusses the contribution of thrombospondin to processes such as morphogenesis, metastasis, hemostasis, and malaria infection. Information regarding thrombospondin's cell receptor and future directions of research are also considered. Thrombospondin will be an important reference for hematologists, cell biologists, developmental biologists, biochemists, artificial organ engineers, and others interested in this vital protein.
Regulatory Proteolytic Enzymes and Their Inhibitors
Regulatory Proteolytic Enzymes and Their Inhibitors consists of contributed papers from the 11th Meeting of the Federation of European Biochemical Societies in Copenhagen in 1977. This collection describes the role of proteases in the physiological regulation, a matter of the activation and de-activation of enzymes. The text also discusses the activation mechanism of pepsinogen and other acid protease zymogens. One paper reviews a discovery — that of a separate and distinct class of precursors, the pre-secretary proteins, and then discusses other studies on preproinsulin. The text then discusses the primary structures and presumed functions of immunoglobulin precursors. Another paper conti...
