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The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development fo...
The agricultural activities are often based on individual producer's decisions and on their attitudes, knowledge and level of technology. It is however also based on political and economic considerations, attitudes and opinions from the society. Thus, continuously updated scientifically based knowledge, both from an environmental, social and economic view, need to be disseminated and applied with a much increased ambition. Technological facts may be well known, but still strong social and economic reasons and pressure from outside to make short term profits hinders the appropriate application of relevant measures. This is the reason why we have all parts of the sustainability concept covered in our texts: the ecological, the social, the economical, and the institutional/juridical. "Sustainable agriculture" has become a popular way of expressing that what society wants is an environmentally sound, productive, economically viable, and socially desirable agriculture.