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Antineoplastic and Immunosuppressive Agents
Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of knowledge in this field has made it progressively more difficult to do justice to all aspects of this topic, and it is possible that the present handbook, more than four years in preparation, may be the last attempt to survey in a. single volume the entire field of drugs em ployed in cancer chemotherapy and immunosuppression. Even in the present instance, it has proved necessary for practical reason...
Studies in Natural Products Chemistry
Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures, which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up to the pharmaceutical industry exciting opportunities in the field of new drug development. The series covers all of the above as well as the synthesis, testing and recording of the medicinal properties of natural products. - Describes the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - A valuable source for researchers in natural product and medicinal chemistry
Advances in Chemotherapy
Advances in Chemotherapy, Volume 2 provides comprehensive and authoritative surveys of progress in all fields of experimental and applied chemotherapy. This book is composed of six chapters, and begins with a discussion on the chemical control of nematodes in plants and the chemistry, biochemistry, and anti-infectious properties of cephalosporin group antibiotics. The succeeding chapters describe the antineoplastic activity of olivomycin group antibiotics; the chemotherapeutic action against malignancies of purines and pyrimidines; and the specific relation of these structures to nucleic acids and cell nuclei, which extends the range of activity of these compounds to viral and protozoan infections. These topics are followed by a presentation of the application of chemotherapy to neoplastic diseases of man, with an emphasis on the complex field of drug response in acute leukemia. The final chapters consider the special problems that are involved in the chemotherapy of tuberculosis as applied in developing countries, particularly in India. This book will be of value to chemists and medical biologists.
Geometry of Harmonic Maps
Harmonic maps are solutions to a natural geometrical variational prob lem. This notion grew out of essential notions in differential geometry, such as geodesics, minimal surfaces and harmonic functions. Harmonic maps are also closely related to holomorphic maps in several complex variables, to the theory of stochastic processes, to nonlinear field theory in theoretical physics, and to the theory of liquid crystals in materials science. During the past thirty years this subject has been developed extensively. The monograph is by no means intended to give a complete description of the theory of harmonic maps. For example, the book excludes a large part of the theory of harmonic maps from 2-dim...
THERAPEUTIC REVOLUTION The History of Medical Oncology from Early Days to the Creation of the Subspecialty
Cancer is a disease responsible for several million annual deaths among humans, worldwide. However, advances in healthcare - which include breakthroughs in science and medicine as well as access to medical treatment - have improved the survival rate of cancer patients over the last few decades. Therapeutic Revolution relates the story of one of the great scientific tales of the twentieth century: how the field of medical oncology was created and its development owing to medical and scientific breakthroughs. The book unfolds the pre-clinical and clinical concepts and innovations that led to the creation of the medical subspecialty now known as medical oncology. Therapeutic Revolution is the f...
Études sur les Groupes Abéliens / Studies on Abelian Groups
Liste des participants et des conferences Table des matieres BAER R. Kollineationen primaerer Praemoduln [1] 1 [2] BAER R. Dualisierbare I!oduln und Praemoduln 37 [3] BEAtJ:IOllT R.A. Abelian groups Gwhich satisty G :: G EPK for every direct summand K of G 69 Sous-groupes fonctoriels et topologies [4J CHARLES B. 75 CUTLER D.O.A topology for primary abelian groups 93 [5J [6] FALTINGS K. Automorphismengruppen endlicher abelscher p-gruppen. 101 [7] FUCHS L. Note on purity and algebraic compactness for modules 121 [8] GP. ABE P.J. Der iterierte Ext-Funktor, seine Periodicität und die dadurch definierten Klassen abelscher Gruppen -- 131 The Jacobson radieal of seme endomorphism rings 143 HAIlW F...
