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An Oprah's Book Club Pick #1 New York Times Bestseller “A mystery, a thriller, a ghost story, and a literary tour de force . . . an authentic epic, long and lush, full of back story and observed detail . . . the author exercises a certain magic that catches and holds our attention, a magic that is undeniably his own.”—Los Angeles Times Book Review Born mute, speaking only in sign, Edgar Sawtelle leads an idyllic life on his family’s farm in remote northern Wisconsin, where they raise and train an extraordinary breed of dog. But when tragedy mysteriously strikes, Edgar is forced to flee into the vast neighboring wilderness, accompanied by three yearling dogs. He comes of age in the wi...
Due to renovations to EDGAR, the new fifth edition of EDGAR Filer Handbook is more essential than ever. All procedures to assemble, validate and transmit filings to EDGAR are entirely new as the DOS-based EDGARLink is replaced by the new EDGAR Filing web site. Prepared by experts with an intimate working knowledge of the EDGARLink system, the Handbook helps you stay current with the latest SEC electronic reporting procedures. It explains step-by-step how to prepare and submit documents for electronic filing precisely and efficiently. Updated to incorporate all the new and revised procedures through EDGAR and EDGARLink Release 7.0.f, you get hands-on assistance to help you make sense of new E...
Immunopharmacology: A New Discipline of Immense Potential Among the looming triumphs of the biologic revolution is the rapidly developing understanding of the mechanisms of bodily defense. In the short span of 35 years, knowledge of immunologic machinery has progressed from crudest description to major understanding in cellular and molecular terms. Antibodies, immunoglobulins, and the complement system have been almost completely defined in detailed molecular terms. Organs, like thymus, spleen and lymph nodes-so long enigmatic black boxes-are beginning to be understood not only in cellular terms but in molecular, physiologic, and endocrinologic terms. With this surging new information about ...
Edgar and Edith are hungry, and it's up to Edgar to bring home something tasty. But just when Edgar finds some delicious sausages, they are taken by The Inspector, a very important-looking rat with a big hat. Poor Edgar and Edith are left with nothing but dry crackers and pickles for dinner. That is, until one day, when The Inspector is all fattened up, and Edgar does some inspecting of his own... "A hilarious tale of confidence, tricks and comeuppance, with deviously delectable pictures" - Metro
Half Apache and mostly orphaned, the adventures of Edgar Presley Mint begin on an Arizona reservation at the age of seven, when the mailman's jeep accidentally runs over his head. Shunted from the hospital to a reform school to a Mormon foster family, comedy and trouble accompany Edgar - the irresistible innocent who never truly loses heart, and whose quest for the mailman leads him to an unexpected home. This riveting picaresque novel has become an international best-seller.
At the Augusta National Golf Course, home of the Masters, the spring grass is green and the world's most famous golfers are gathered. It looks as if it's going to be another splendid tournament. Until Melvin Newton's body is found in Eisenhower Pond, the apparent victim of a suicide. But what looks like suicide to most, looks like murder to John Morris, a retired AP sportswriter, and his spirited, sexy friend Julia Sullivan. Newton, a wealthy businessman and elite member of the club, is the type of man to be killed, not the type to kill himself, Morris reflects. He was a man with many enemies and few friends. But the list of suspects is enormous enough for Morris to include himself. Who didn...
This book is the outcome of a meeting held in Davos, Switzerland, February 7-12, 1982 focused primarily on mononuclear phagocytes and on natural killer (NK) cells. This IX International RES Congress was attended by 489 scientists from 31 countries and there were 340 scientific presentations in oral or poster session. The essential purpose of the Congress was to bring together scientists representing various aspects of mononuclear phagocyte biology to review and examine cri~ically the effects and mechanisms of macrophage growth control as well as the participatio~ of these cells in the afferent and efferent limbs of the immune response. Additional topics included the production and distribution of mono nuclear phagocytes; the intrinsic and extrinsic regulation of these cells; and the origin, nature, function and regulation of NK cells. The ultimate goal of the Congress was to enhance communication between scientists in various countries and disciplines so that new research directives could be defined with which to explore basic aspects of macrophage and NK cell participation in the control of cancer and infection.