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Natural Products and Drug Discovery
Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug d...
Textbook of Drug Design and Discovery, Third Edition
Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.
Digital Television Systems
A concise yet detailed guide to the standards applying to fixed-line and mobile digital television and the underlying principles involved.
Latin America
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FRBR, Before and After
Coyle’s expert ability to draw from the deep historical background of cataloging theory to illuminate the potentials of library data on the Web helped win her the 2011 ALCTS Outstanding Publication Award. Here she persuasively argues that to more effectively connect library users with books, movies, music, computer games, and other resources, library data needs to move beyond FRBR towards a more integrative approach to bibliographic models. But doing so requires fundamental changes in the approach to library data. Combing a sweeping perspective with a critical eye, she assesses how we define a work in the bibliographic world. Showing how bibliographic models reflect technology and our assu...
The Gospel According to Jesus Christ
Saramago's Jesus is the son not of God but of Joseph. Mary Magdalene is his lover not his convert. In the wilderness he tussles not with the Devil – a kindly and necessary evil – but with God, a fallible, power-hungry autocrat. And he must die not for the sins of the fathers but for the sins of the Father. By investigating these simple inversions Saramago has woven a dark parable; a secular gospel of astonishing richness and depth. ‘An original, wild and beautiful book’ Times Literary Supplement
Digital Document Analysis and Processing
One possible solution to the increased amount of paper generated by mankind over recent years is to use the computer and its associated possibility of storing digital information. Through digitisation, the image of a paper can be stored in a digital file. With the development of new storage mediums with even larger capacity and faster access times, it is possible to put a complete collection of books in a single DVD or a small flash drive. This brought forth a possible solution to the problem of carrying and copying the information. But as new opportunities appear to us, we create new possibilities and new problems with them. In this way, carrying and copying moved away from being the centre of the problem. This book covers the main aspects of document analysis and processing, including digitisation, storage, thresholding, filtering, segmentation and automatic recognition.
Human Centered Management and Crisis
Human Centered Management and Crisis: Disruptions, Resilience, Wellbeing and Sustainability is the new edited book of the Human Centered Management (HCM) Series developed to respond to surmounting concerns of global audiences and human centered scholars, practitioners and students searching for answers to better and objectively understand the effects of unprecedented Covid-19 pandemic disruptions and ongoing crises, affecting the wellbeing of people and workplaces since 2019. The effects linger and solutions are pressing. This new HCM volume presents analytical expertise and practical experiences of a team of international HCM scholars and practitioners targeting objective assessment of caus...
