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The three sections of this volume deal with topics of broad interest. The first deals with cetyl alcohol and is a most comprehensive study of this essential ingredient in the cosmetic and pharmaceutical industry, with an explanation of its functionality. The second is a most comprehensive, up-to-date review of acid/base interactions of a variety of materials, including small molecules, proteins and polyelectrolytes. The third section describes the combined radiochemical and electrochemical methods in the evaluation of the properties of solids in contact with solutions.
Pharmaceutical manufacture is very exacting – for example, drugs must be uniform in size, shape, efficacy, bioavailability, and safety. The presence of different polymorphs in drug production is a serious problem, since different polymorphs differ in bioavailability, solubility, dissolution rate, chemical and physical stability, melting point, color, filterability, density, and flow properties. Fine Particles in Medicine and Pharmacy discusses particle size, shape, and composition and how they determine the choice of polymorph of a drug.
The important role of ?nely dispersed matter and surfaces in medicine is not always fully understood and appreciated. Speci?cally, ?ne particles (solid or liquid) in the size range of several nanometers to several micrometers have a tremendous effect on our lives, because they can be bene?cial or detrimental to our well-being. Such particles are present in living bodies as red blood cells or cholesterol crystals in the gall bladder. They are ubiquitous in the environment, where they can cause many diseases, such as asbestosis, silicosis, and black lung disease, but they are also used in diagnostic tests, drug delivery, and numerous other applications. More recently, evidence has become avail...
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