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Oncogenomics and Cancer Proteomics
Oncogenomics and Cancer Proteomics - Novel Approaches in Biomarkers Discovery and Therapeutic Targets in Cancer presents comprehensive reviews of the most common cancers from bench to bedside applications by an international team of experts. This book will contribute to the scientific and medical community by providing up-to-date discoveries of oncogenomics and their potential applications in cancer translational research. It is intended for students, scientists, clinicians, oncologists and health professionals working in cancer research.
Epigenetic Regulation of Cancer - Part B
Epigenetic Regulation of Cancer, Part B, Volume 383 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic control of cell signaling in cancer stem cells, Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications, Epigenetic regulation in pancreatic cancer, Epigenome Editing in Cancer: Advances and Challenges for Potential Therapeutic Options, Inhibition of epigenetic mechanisms in cancer, and Epigenetics as a determinant of radiation response in cancer. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Free Energy Calculations
Free energy constitutes the most important thermodynamic quantity to understand how chemical species recognize each other, associate or react. Examples of problems in which knowledge of the underlying free energy behaviour is required, include conformational equilibria and molecular association, partitioning between immiscible liquids, receptor-drug interaction, protein-protein and protein-DNA association, and protein stability. This volume sets out to present a coherent and comprehensive account of the concepts that underlie different approaches devised for the determination of free energies. The reader will gain the necessary insight into the theoretical and computational foundations of th...
International Human Rights Law in a Global Context
The international human rights system remains as dynamic as ever. If at the end of the last century there was a sense that the normative and institutional development of the system had been completed and that the emphasis should shift to issues of implementation, nothing of the sort occurred. Even over the last few years significant changes happened, as this book amply demonstrates. We hope that this Manual makes a contribution to the development of International Human Rights Law and is of interest for those working in the field of promotion and protection of human rights. The book is the result of a joint project under the auspices of HumanitarianNet, a Thematic Network led by the University of Deusto, and the European Inter-University Centre for Human Rights and Democratisation (EIUC, Venice).
International Environmental Law
A concise, clear, and legally rigorous introduction to international environmental law and practice covering the very latest developments.
United Nations Juridical Yearbook, 1987
Covers legislative texts and treaty provisions relating to the legal status of the UN and related intergovernmental organizations; a review of the legal activities, the treaties concerning international law, and the decisions of administrative tribunals of the UN and related intergovernmental organizations; selected legal opinions of the secretaries and judicial decisions on questions relating to the UN and related intergovernmental organizations; and a bibliography. Annotation copyrighted by Book News, Inc., Portland, OR
Principles of Bioenergetics
Principles of Bioenergetics summarizes one of the quickly growing branches of modern biochemistry. Bioenergetics concerns energy transductions occurring in living systems and this book pays special attention to molecular mechanisms of these processes. The main subject of the book is the "energy coupling membrane" which refers to inner membranes of intracellular organelles, for example, mitochondria and chloroplasts. Cellular cytoplasmic membranes where respiratory and photosynthetic energy transducers, as well as ion-transporting ATP-synthases (ATPases) are also part of this membrane. Significant attention is paid to the alternative function of mitochondria as generators of reactive oxygen species (ROS) that mediate programmed death of cells (apoptosis and necrosis) and organisms (phenoptosis). The latter process is considered as a key mechanism of aging which may be suppressed by mitochondria-targeted antioxidants.
International Protection of Human Rights: Achievements and Challenges
At the beginning of the nineties, there was an expectation within the human rights community that the next decade would be a period of consolidation for the international human rights regime. This did not happen. In fact, the human rights regime underwent dramatic changes in response to new circumstances. We have tried to highlight both the achievements and the challenges ahead in this Manual, the result of a joint project under the auspices of HumanitarianNet, a Thematic Network on Humanitarian Development Studies leaded by the University of Deusto (Bilbao, the Basque Country, Spain), and the European Inter-University Centre for Human Rights and Democratisation (EIUC, Venice, Italy).
DNA Helicases and DNA Motor Proteins
In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines. The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can ...
Heroes, Martyrs, and Political Messiahs in Revolutionary Cuba, 1946-1958
A leading scholar sheds light on the experiences of ordinary Cubans in the unseating of the dictator Fulgencio Batista In this important and timely volume, one of today’s foremost experts on Cuban history and politics fills a significant gap in the literature, illuminating how Cuba’s electoral democracy underwent a tumultuous transformation into a military dictatorship. Lillian Guerra draws on her years of research in newly opened archives and on personal interviews to shed light on the men and women of Cuba who participated in mass mobilization and civic activism to establish social movements in their quest for social and racial justice and for more accountable leadership. Driven by a sense of duty toward la patria (the fatherland) and their dedication to heroism and martyrdom, these citizens built a powerful underground revolutionary culture that shaped and witnessed the overthrow of Batista in the late 1950s. Beautifully illustrated with archival photographs, this volume is a stunning addition to Latin American history and politics.
