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Cerebral endothelial and glial cells are more than bricks in the Great Wall of the brain: insights into the way the blood-brain barrier actually works (Celebrating the centenary of Goldman’s experiments)
When Ehrlich discovered the first evidence of the blood-brain barrier in 1885, he probably did not perceive the Great Wall that remained hidden from consciousness inside the central nervous system. Ehrlich had observed that acidic vital dyes did not stain the brain if they were injected into the blood stream. A century ago (1913), Goldman showed that the injection of trypan blue in the cerebrospinal fluid stained only the brain, but not the other organs. For almost a century it was thought that the blood-brain barrier (BBB) consisted in a physical barrier, resulting from the restricted permeability of the cerebral endothelial cell layer, as they are joined by tight junctions. However, as sci...
Second Language and Heritage Learners in Mixed Classrooms
This book addresses the complexity of mixed language classroom learning environments in which heritage learners (HL) and second language (L2) learners are concurrently exposed to language learning in the same physical space. Heritage speakers, defined widely as those exposed to the target language at home from an early age, tend to display higher oral proficiency and increased intercultural proficiency but lesser metalinguistic and grammatical awareness than L2 learners. The theoretical and pedagogical challenges of engaging both types of learners simultaneously without polarizing the classroom community dictates the need for well-defined, differentiated learning strategies; in response this book offers best practices and reproducible pedagogical initiatives and methodologies for different levels of instruction. The chapters address themes including translanguaging, linguistic identity, metalinguistic awareness and intercultural competence, with contributions from Europe, Africa and the United States.
Biomarkers in Drug Hypersensitivity
Biomarkers, especially those based on pharmacogenomics testing, have proved to be extremely useful for type A adverse drug reactions. Clinical practice guidelines based on biomarker testing are presently being developed and updated for type A adverse drug reactions. In contrast, little attention has been paid to the potential use of biomarkers in type B adverse reactions, characterized by the occurrence of reactions not directly related to the pharmacological properties of the drug. Drug-induced hypersensitivity belongs to those type B reactions. Drug-induced hypersensitivity reactions involve complex mechanisms that include, among others, the metabolic activation and haptenization of drug m...
Social Justice in Spanish Golden Age Theater
This book explores early modern Spanish plays through the lens of social justice, extending its analysis to contemporary adaptations and how they can be used as a tool for achieving social justice today.
Querying Difference in Theatre History
Terms such as race, ethnicity, otherness, and pluralism are becoming increasingly problematic as we grapple with issues of identity in the “post-multicultural” discursive landscape of the twenty-first century. Querying Difference in Theatre History comprises sixteen scholarly case studies in which authors tease out the limitations of contemporary discourse concerning ideas of difference in theatre history today. The essays then incorporate new approaches, theories, and critical vocabulary for dealing with such issues. Unlike other works that address similar subjects, this volume arranges essays by mode of inquiry rather than by “kind of difference.” It offers essays that are complex ...
Impact of Aerosols (Saharan Dust and Mixed) on the East Mediterranean Oligotrophic Ecosystem, Results from Experimental Studies
In oligotrophic environments, dust and nutrient inputs via atmospheric routes are considered important sources of macro-nutrients and micro-trace metals fuelling primary and secondary production. Yet, the impact of these dust inputs on the microbial populations is not fully investigated in the Eastern Mediterranean Sea (EMS). The response of oligotrophic systems to dust inputs, whether as positive or negative feedbacks to autotrophic and heterotrophic production and thus to biogeochemical cycling, is important to examine further. Experimental studies have explored nutrient additions in various combinations to determine the limiting resource to productivity or N2 fixation. Recent experimental...
