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AACR 2022 Proceedings: Part B April 11-13
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
Regulation and Function of Transcription Factor MEF2C in Vascular Development
Blood vessel development in vertebrates starts early during embryogenesis with the de novo formation of blood vessels through the process of vasculogenesis. During vasculogenesis, endothelial progenitor cells coalesce into tubular structures. Pericytes and smooth muscle cells then surround these tubes to form functioning blood vessels. Myocyte enhancer factor 2 (MEF2) transcription factors have been shown to play a critical role in the differentiation of cardiac and skeletal muscle. MEF2C is also expressed in several other cell types, including smooth muscle and endothelial cells, yet little is known about the transcriptional pathways in which MEF2C participates, particularly during vascular...
Alumni Directory
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Perspectives
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Expression and Function of the Histidine-rich Calcium-binding Protein
Although we did not observe any significant defects in calcium handling in the hearts of HRC null mice, expression of the cardiac isoform of triadin (triadin 1) was upregulated in these hearts to compensate for the loss of HRCBP. These observations suggest that HRCBP may indirectly modulate inactivation of the ryanodine receptor (RyR) in response to changes in the luminal calcium concentration. Specifically, HRCBP may antagonize the inhibitory effect of calsequestrin on the ability of triadin to stabilize the open conformation of the RyR as luminal calcium stores are depleted.
Vital Signs 2005-2006
'VITAL SIGNS does for the environment what stock market indicators do for the City. But it says more about the future of our world than the FTSE ever can ' BBC Wildlife Magazine 'VITAL SIGNS is a sharply focused snapshot of the world Ideal for dipping into it makes fascinating reading ' New Agriculturalist 'The scope of the book is vast ... the presentation is clean and seamless ' Humanitarian Affairs Review 'An enlightening insight into the relationship between the environment and human activity ' Green Futures VITAL SIGNS 20052006 provides up-to-the-minute information on global warming, population growth, military spending, HIV/AIDS, economic equity, the trade in drugs and a whole range of other environmental, developmental, social, political and economic issues. By distilling 25 'vital signs' of our times from thousands of governmental, industrial and scientific sources, this book allows reader s to track key indicators that show our progress in issues that too often escape the attention of the news media, world leader s and economic experts . Each theme is presented in both text and two colour graphics, providing a thorough, well-documented and very accessible over view.
