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Glucocorticoid Action
Glucocorticoids regulate multiple metabolic and developmental processes and play a vital role in the maintenance of basal and stress-related homeostasis. For the last 50 years, pharmacologic doses of glucocorticoids have been used in the treatment of inflammatory, autoimmune, and lymphoproliferative diseases and in the prevention of allograft rejection, while substitution doses have been employed in the management of adrenocortical insufficiency. aspects of glucocorticoid action, in particular, (i) the impact of maternal and early life stress on stress-related gene regulation in the offspring; (ii) the importance of glucocorticoids and their receptors; (iii) further understanding of the mech...
Introduction to Translational Cardiovascular Research
The term “Translational Research” reflects today’s integration of basic research (“bench”) findings with the clinical practice of medicine, and in a wider scope the application of results from the individual patient (“bedside”) to entire populations for the improvement of public health. This book offers future researchers a stimulus in many aspects of cardiovascular research, so as to promote their interest in future fields of cardiovascular disease, diagnosis and treatment. Introduction to Translational Cardiovascular Research discusses the fundamental and important aspects of the topic. It describes the renin-angiotensin-aldosterone system, the beta adrenergic receptors and t...
Yearbook of Pediatric Endocrinology 2011
The body of knowledge in most medical specialties is rapidly expanding, making it virtually impossible to follow all advances in clinical and basic sciences that are relevant to a given field. This is particularly true in pediatric endocrinology, at the cross-road of pediatrics, endocrinology, development and genetics. Providing abstracts of articles that report the year’s breakthrough developments in the basic sciences and evidence-based new knowledge in clinical research and clinical practice that are relevant to the field, the Yearbook of Pediatric Endocrinology 2011 keeps busy clinicians and scientists, pediatric endocrinologists, and also pediatricians and endocrinologists informed on...
Adrenal Glands
- Over 200 exquisite illustrations, ranging from intraoperative photographs, line drawings, diagnostic images, pathology slides, tables and graphs are available to make each case discussed comprehensible and easy to follow. - Traditional and novel therapeutic recommendations are introduced and the latest developments in minimal-access operative techniques are discussed and reviewed. - Focuses on a teamwork oriented approach that identifies the necessary communications amongst the many medical disciplines when dealing with adrenal disorders.
ACTH Action in the Adrenal Cortex: From Molecular Biology to Pathophysiology
By stimulating adrenal gland and corticosteroid synthesis, the adrenocorticotropic hormone (ACTH) plays a central role in response to stress. In this Research Topic, a particular attention has been given to the recent developments on adrenocortical zonation; the growth-promoting activities of ACTH; the various steps involved in acute and chronic regulation of steroid secretion by ACTH, including the effect of ACTH on circadian rhythms of glucocorticoid secretion. The Research Topic also reviews progress and challenges surrounding the properties of ACTH binding to the MC2 receptor (MC2R), including the importance of melanocortin-2 receptor accessory protein (MRAP) in MC2R expression and funct...
The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease
Cushing ́s syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life expectancy. This book reviews the role of cortisol in the human body, focusing on the effects of excess cortisol due to Cushing’s syndrome as well as the role of the HPA axis in metabolism, inflammation, and neuropsychiatric function. The volume will cover basic mechanistic data, clinical outcomes data, and novel therapies. Also discussed are everything from abnormalities of the HPA axis, to the role of the HPA axis in the development of neuropsychiatric disorders and metabolic disorders, to new definitions of Cushing’s remission and recurrence. The Hypothalamic Pituitary Adrenal Axis in Health and Disease will provide a comprehensive and multi-disciplinary review of the pathophysiology and outcomes of excess cortisol in the human body and brain as well as the role of the HPA axis in other disease states.
Yearbook of Pediatric Endocrinology 2010
The body of knowledge in most medical specialties is rapidly expanding, making it virtually impossible to follow all advances in clinical and basic sciences that are relevant to a given field. This is particularly true in pediatric endocrinology, at the cross-road of pediatrics, endocrinology, development and genetics. Providing abstracts of articles that report the year's breakthrough developments in the basic sciences and evidence-based new knowledge in clinical research and clinical practice that are relevant to the field, the Yearbook of Pediatric Endocrinology 2010 keeps busy clinicians and scientists, pediatric endocrinologists, and also pediatricians and endocrinologists informed on n...
Childhood Obesity
The prevalence of overweight and obesity has significantly increased over the past few decades and is linked to metabolic diseases across the lifespan. Its etiology has been attributed to a large number of sociodemographic, behavioral (e.g. unhealthy nutrition, low levels of physical activity), perinatal, and clinical risk factors, which are active already from childhood and adolescence. Still, their exact role, interplay, and mechanisms implicated in this process remain unclear. The trends of childhood obesity call for actions regarding the prevention and management of this disease early in life. The Special Issue "Childhood Obesity: Nutrition and Lifestyle Determinants, Prevention and Management" aims to host original articles, systematic reviews or meta- analyses that will advance the current knowledge on the role of health behaviors, especially of nutrition, on the development of overweight or obesity in childhood and adolescence, provide valuable information about the nutritional habits of overweight/obese children and adolescents, and describe novel approaches via lifestyle modification for the prevention or management of obesity in youth.
Hormone Resistance and Hypersensitivity
Over recent years, impressive advances in genetic/epigenetic technology have greatly improved the understanding of the pathogenesis of pediatric endocrine diseases due to hormone resistance and hypersensitivity.This book presents reviews of thyroid hormone and thyroid hormone receptor resistance, and genetics and epigenetics of parathyroid hormone resistance. Abnormalities of the pituitary-gonadal axis affecting puberty as well as androgen receptor are covered. Novel insights into the diseases affecting ACTH, glucocorticoid and aldosterone receptors are discussed. Further chapters address new aspects of the physiology of the GH and IGF-1 axis as well as the diseases related to GH-IGF-1 receptor and post-receptor signaling defects. A key chapter on metabolic insights into insulin resistance is also included. Covering clinical and genetic aspects of hormone resistance and hypersensitivity, this book will be a useful tool in the hands of scientists, physicians and other healthcare professionals who wish to be up to date with novel research findings in this area.
Childhood Obesity
The prevalence of overweight and obesity has significantly increased over the past few decades and is linked to metabolic diseases across the lifespan. Its etiology has been attributed to a large number of sociodemographic, behavioral (e.g. unhealthy nutrition, low levels of physical activity), perinatal, and clinical risk factors, which are active already from childhood and adolescence. Still, their exact role, interplay, and mechanisms implicated in this process remain unclear. The trends of childhood obesity call for actions regarding the prevention and management of this disease early in life. The Special Issue "Childhood Obesity: Nutrition and Lifestyle Determinants, Prevention and Management" aims to host original articles, systematic reviews or meta- analyses that will advance the current knowledge on the role of health behaviors, especially of nutrition, on the development of overweight or obesity in childhood and adolescence, provide valuable information about the nutritional habits of overweight/obese children and adolescents, and describe novel approaches via lifestyle modification for the prevention or management of obesity in youth.
