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Cells of the myeloid lineage display diverse roles and functions both in tissue homeostatic conditions and during the development of liver diseases. Hepatic myeloid cells such asKupffer cells exert immune surveillance while maintaining immune tolerance. This helps to prevent excessive immune stimulation upon encounter with gut-derived antigens from food and commensal microbes, or rapidly identifying and eliminating pathogens. Myeloid cells also exhibit a dual role by contributing to both the initiation and progression of liver diseases. During liver inflammation, myeloid cells secrete cytokines and chemokines that promote chemotaxis and tissue damage. Further down the process they can undergo reprogramming into pro-resolving, anti-inflammatory cells. In extremis, these can lead to loss of liver function and development of fibrosis and cirrhosis. Liver myeloid cells can also dictate the progress of hepatic malignancy by either promoting the infiltration and activation or suppressing the activities of effector and/or cytotoxic T cells.
Can the Balkans ever become a peaceful peninsula like that of Scandinavia? With enlightened backing, can it ever make common cause with the rest of Europe rather than being an arena of periodic conflicts, political misrule, and economic misery? In the last years of the twentieth century, Western states watched with alarm as a wave of conflicts swept over much of the Balkans. Ethno-nationalist disputes, often stoked by unprincipled leaders, plunged Yugoslavia into bloody warfare. Romania, Bulgaria and Albania struggled to find stability as they reeled from the collapse of the communist social system and even Greece became embroiled in the Yugoslav tragedy. This new book examines the politics and international relations of the Balkans during a decade of mounting external involvement in its affairs. Tom Gallagher asks what evidence there is that key lessons have been learned and applied as trans-Atlantic engagement with Balkan problems enters its second decade. This book identifies new problems: organized crime, demographic crises of different kinds, and the collapse of a strong employment base. This is an excellent contribution to our understanding of the area.
The 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering, contains the papers presented at the 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering joint event. It is a valuable resource for chemical engineers, chemical process engineers, researchers in industry and academia, students, and consultants for chemical industries. Presents findings and discussions from the 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering joint event