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This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present i...
Within this text, for the first time the synthesis, structural characteristics, physical properties, applications and potential applications of polysiloxanes, polycarbosilanes, polysilazanes, polysilanes, and other silicon-containing polymers are detailed. For years to come this book will be the first point of entry for those seeking to learn about the very significant differences that exist between carbon-based polymers and those with silicon in their backbone.