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Neural Plasticity and Memory
A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Plasticity in the Central Nervous System
Catalyzed by the development of new neurobiological and behavioral techniques as well as new conceptual and theoretical approaches to the study of the relationship between brain and behavior, research exploring brain functions enabling learning and memory has greatly accelerated in recent years. The chapters in this book reflect current theoretical approaches to the study of brain and memory and provide new insights concerning the cellular bases of memory and the differential involvement of brain systems in different forms of memory. By presenting up-to-date summaries of research investigating brain mechanisms underlying learning and memory, these chapters help to place current findings in a...
Olfaction and Taste XI
In this compendium of current studies on olfaction and taste - the most comprehensive yet to appear in this series - the chemical senses are elucidated from points of view ranging from anatomy, electrophysiology, molecular biology (especially chemoreceptor gene cloning), biochemistry, and psychophysics to the latest clinical and technological applications of chemosensory research. Specific topics include the structure and function of the tastebud and olfactory epithelium; the genetics and mechanisms of olfactory and taste transduction; the chemistry and function of flavor compounds; the psychophysics of taste and olfaction in daily human life; the brain mechanisms of coding, learning, and me...
Memory and motivational/emotional processes
It is well established that memory for emotional information is generally better than for neutral information. This Research Topic comprises a set of papers focusing on memory and its relation with motivational and emotional processes, ranging from electroencephalographic evidences of emotional modulation of memory systems, to the role of neurotransmitters/neuromodulators (i.e. endocannabinoid, glucocorticoid, serotonin, noradrenergic, dopaminergic systems), and second messengers on emotional memory, and the specific involvement of cerebral areas on the relation between memory and motivational/emotional processes (i.e. prefrontal cortex, amygdala, accumbens). In particular, some of the topic...
Extinction Learning from a Mechanistic and Systems Perspective
Throughout their lifetime, animals learn to associate stimuli with their consequences. Following memory acquisition and consolidation, circumstances may arise that necessitate that initially learned behaviour is no longer relevant. The ensuing process is called extinction learning and involves a novel and complex learning procedure that involves a large number of neural entities. While the neural fundaments of the initial acquisition are well studied, our understanding of the behavioural and neural basis of extinction is still limited and derives mostly from rodent data acquired through fear conditioning paradigms. Fear conditioning and extinction in rodents is a spectacularly successful par...
Neurodegeneration: From Genetics to Molecules
Chronic degenerative diseases are one of the major public health problems, particularly those affecting the nervous system. They are characterized by the degeneration of specific cell populations that include several pathologies which contribute significantly to morbidity and mortality in the elderly population. Therefore, in recent years, the study of neuroscience has gained significant importance. Most of these neurodegenerative disorders are the result of a complex interaction between genetic and environmental factors that generate progression and can even determine its severity. The presence of mutations in genes as LRRK2, SNCA, PARK7, PARK2 or PINK1 is associated with Parkinson's diseas...
Chemosensory Learning and Memory
The contribution of research in the chemosensory field to advancing knowledge on learning and memory mechanisms has a long tradition. At the middle of the twentieth century, behavioural data provided evidence that taste and olfactory cues led to robust long-lasting memories after single learning episodes. The peculiar features of some of these types of learning, such as conditioned taste aversion in mammals, were a challenge for learning theory at the time, which was modified in order to integrate the new findings. In the following decades, the reliability of the behavioural models favoured the application of anatomical, neurophysiological and pharmacological techniques prompting great progr...
The Stakes of History
A leading scholar of Jewish history’s bracing and challenging case for the role of the historian today Why do we study history? What is the role of the historian in the contemporary world? These questions prompted David N. Myers’s illuminating and poignant call for the relevance of historical research and writing. His inquiry identifies a number of key themes around which modern Jewish historians have wrapped their labors: liberation, consolation, and witnessing. Through these portraits, Myers revisits the chasm between history and memory, revealing the middle space occupied by modern Jewish historians as they work between the poles of empathic storytelling and the critical sifting of sources. History, properly applied, can both destroy ideologically rooted myths that breed group hatred and create new memories that are sustaining of life. Alive in these investigations is Myers’s belief that the historian today can and should attend to questions of political and moral urgency. Historical knowledge is not a luxury to society but an essential requirement for informed civic engagement, as well as a vital tool in policy making, conflict resolution, and restorative justice.
Horizons in Systems Neuroscience 2022
We are delighted to present the “Horizons in Systems Neuroscience” article collection. This collection showcases high-impact, authoritative, and reader-friendly review articles covering the most topical research at the forefront of systems neuroscience. All contributing authors were individually nominated by the Chief Editors of the Journal in recognition of their prominence and influence in their respective fields. The cutting-edge work presented in this article collection highlights the diversity of research performed across the entire breadth of the systems neuroscience field and reflects on the latest advances in the theory, experiment, and methodology with applications to compelling problems in academic and translational research.
Conditioning
I would like to thank all those who contributed to the success of this symposium and its proceedings by providing the material herein. The purpose of the symposium was to examine current know ledge of the brain's function in supporting conditioned behavior. The research of those assembled has led to much of this knowledge. It is a pleasure to acknowledge the organizational help of Drs. D. Alkon, D. Cohen, J. Disterhoft, T. Thach, R. Thompson, and L. Voronin, and also the UCLA Brain Research Institute, the UCLA Mental Re tardation Research Center, and Dolores Squires, who assisted faith fully in the administrative organization of the symposium. Special thanks are also due the publisher and pu...
