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Synthetic Biology engineering complexity and refactoring cell capabilities
One of the key features of biological systems is complexity, where the behavior of high level structures is more than the sum of the direct interactions between single components. Synthetic Biologists aim to use rational design to build new systems that do not already exist in nature and that exhibit useful biological functions with different levels of complexity. One such case is metabolic engineering, where, with the advent of genetic and protein engineering, by supplying cells with chemically synthesized non-natural amino acids and sugars as new building blocks, it is now becoming feasible to introduce novel physical and chemical functions and properties into biological entities. The rule...
Synthetic Biology-Guided Metabolic Engineering
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Civil Structural Health Monitoring
This volume gathers the latest advances and innovations in the field of structural health monitoring, as presented at the 8th Civil Structural Health Monitoring Workshop (CSHM-8), held on March 31–April 2, 2021. It discusses emerging challenges in civil SHM and more broadly in the fields of smart materials and intelligent systems for civil engineering applications. The contributions cover a diverse range of topics, including applications of SHM to civil structures and infrastructures, innovative sensing solutions for SHM, data-driven damage detection techniques, nonlinear systems and analysis techniques, influence of environmental and operational conditions, aging structures and infrastructures in hazardous environments, and SHM in earthquake prone regions. Selected by means of a rigorous peer-review process, they will spur novel research directions and foster future multidisciplinary collaborations.
Cancer Immunotherapy
This volume details multiple areas of new and emerging methods to develop the next generation of immunotherapy treatments. Chapters guide readers through analysis and characterisation of the interactions between tumour and immune cells, and cell engineering tools for cancer treatment, to provide a unique and compelling set of techniques instrumental to work with, and engineer, immune cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cancer Immunotherapy: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Design Procedures for the Use of Composites in Strengthening of Reinforced Concrete Structures
This book analyses the current knowledge on structural behaviour of RC elements and structures strengthened with composite materials (experimental, analytical and numerical approaches for EBR and NSM), particularly in relation to the above topics, and the comparison of the predictions of the current available codes/recommendations/guidelines with selected experimental results. The book shows possible critical issues (discrepancies, lacunae, relevant parameters, test procedures, etc.) related to current code predictions or to evaluate their reliability, in order to develop more uniform methods and basic rules for design and control of FRP strengthened RC structures. General problems/critical issues are clarified on the basis of the actual experiences, detect discrepancies in existing codes, lacunae in knowledge and, concerning these identified subjects, provide proposals for improvements. The book will help to contribute to promote and consolidate a more qualified and conscious approach towards rehabilitation and strengthening existing RC structures with composites and their possible monitoring.
Externally applied FRP reinforcement for concrete structures
In December 1996, CEB established a Task Group with the main objective to elaborate design guidelines for the use of FRP reinforcement in accordance with the design format of the CEB-FIP Model Code and Eurocode2. With the merger of CEB and FIP into fib in June 1998, this Task Group became fib TG 9.3 FRP Reinforcement for concrete structures in Commission 9 Reinforcing and Prestressing Materials and Systems. Finally, as a result of the restructuring of fib’s Commissions and Task Groups at the end of 2014, the Task Group became fib T5.1 FRP Reinforcement for concrete structures, chaired by Stijn Matthys at Ghent University, in Commission 5 Reinforcements. The work of former TG 9.3 and curren...
Pacific Symposium on Biocomputing 2010, Kamuela, Hawaii, USA, 4-8 January 2010
The Pacific Symposium on Biocomputing (PSB) 2010 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2010 will be held on January 4 - 8, 2010 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference. PSB 2010 will bring together top researchers from the US, Asia Pacific, and around the world to exchange research results and address pertinent issues in all aspects of computational biology. It is a forum ...
Protection of Historical Constructions
This book gathers the peer-reviewed papers presented at the 4th International Conference on Protection of Historical Constructions (PROHITECH), held in Athens, Greece, on October 25-27, 2021. The conference topics encompass structural and earthquake engineering, intervention strategies, materials and technologies, digital documentation, architecture and urban planning, cultural heritage, all of which represented by a showcase of case studies covering different construction materials, as well as sustainability, energy efficiency, and adaptation to climate changes. As such the book represents an invaluable, up-to-the-minute tool, providing an essential overview of protection of historical constructions, and offers an important platform to researchers, engineers and architects.
Advances on bond in concrete
Structural behavior of reinforced concrete elements strongly depends on the interaction between the reinforcing bars and the surrounding concrete, which is generally referred as “bond in concrete”. In service conditions, the reinforcement-to-concrete bond governs deformability through the tension stiffening of concrete surrounding the bar as well the crack development and crack width. At Ultimate Limit State, bond governs anchorage and lap splices behavior as well as structural ductility. When plain (smooth) bars were used, the steel-to-concrete bond was mainly associated with “chemical adhesion/friction” that is related to the surface roughness of the rebar. As steel strengths incre...
