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Research in Computational Molecular Biology
This book constitutes the proceedings of the 23rd Annual Conference on Research in Computational Molecular Biology, RECOMB 2019, held in Washington, DC, USA, in April 2019. The 17 extended and 20 short abstracts presented were carefully reviewed and selected from 175 submissions. The short abstracts are included in the back matter of the volume. The papers report on original research in all areas of computational molecular biology and bioinformatics.
STACS 2007
This book constitutes the refereed proceedings of the 24th Annual Symposium on Theoretical Aspects of Computer Science, STACS 2007, held in Aachen, Germany in February 2007. The 56 revised full papers presented together with 3 invited papers address the whole range of theoretical computer science as well as current challenges like biological computing, quantum computing, and mobile and net computing.
Artificial Nucleases
The development of agents capable of cleaving RNA and DNA has attracted considerable attention from researchers in the last few years, because of the immediate and very important applications they can find in the emerging fields of biotechnology and pharmacology. There are essentially two classes of these agents - nucleases that occur naturally inside cells and synthetically produced artificial nucleases. The first class includes protein enzyme nucle ases and catalytic RNA structured ribozymes that perform cleavage of the phosphodiester bonds in nucleic acids according to a hydrolytic pathway in the course of different biochemical processes in the cell. A different pathway is used by some an...
The Core Model
The Core Model: A Collaborative Paradigm for the Pharmaceutical Industry and Global Health Care develops the innovative core model, an organizational research and design paradigm and economic theory that proposes a collaborative approach to resolving global health issues and improving the productivity of drug development. The model proposes that scientific collaboration does not occur in an unstructured manner, but actually takes place within a highly structured order where knowledge is transferred, integrated and finally translated into commercial products. An understanding of this model will help solve the global pharmaceutical industry ́s productivity problems and address important global health care and economic issues. This book is useful to researchers, advanced students, regulators, and management in pharmaceutical industries, as well as healthcare professionals, those working in health economics, and those interested in scientific innovation processes.
Total Marrow Irradiation
This book, written by a team of international experts, concisely reviews the rationale and clinical application of image-guided total marrow irradiation, a rapidly emerging area in radiation oncology and hematopoietic cell transplantation. The aim is to provide the practicing radiation oncologist, hematologist, medical physicist, and bone marrow transplant researcher with a fundamental understanding of key aspects and an appreciation of the increasing significance of total marrow irradiation as conditioning for bone marrow transplantation. Detailed attention is paid to the impacts of recent advances in radiation therapy technology, functional PET and MRI, and understanding of the response of...
The Governor's Dilemma
Through twelve case studies, this book introduces a general theory of indirect governance based on the tradeoff between governor control and intermediary competence.
Atlas of Novel Tectonics
Architects Jesse Reiser and Nanako Umemoto have been generating some of the most provocative thinking in the field for nearly twenty years. With Atlas of Novel Tectonics, Reiser+Umemoto hone in on the many facets of architecture and illuminate their theories with great thought and simplicity. The Atlas is organized as an accumulation of short chapters that address the workings of matter and force, material science, the lessons of art and architectural history, and the influence of architecture on culture (and vice versa). Reiser+Umemoto see architectural design as a series of problem situations, and each chapter is an argument devoted to a specific condition or case. Influenced by a wide ran...
Giotto's Arena Chapel and the Triumph of Humility
"In this book, Henrike Lange takes the reader on a tour through one of the most beloved and celebrated monuments in the world - Giotto's Arena Chapel. Paying close attention to previously overlooked details, Lange offers an entirely new reading of the stunning frescoes in their spatial configuration. The author also asks fundamental questions that define the chapel's place in Western art history. Why did Giotto choose an ancient Roman architectural frame for his vision of Salvation? What is the role of painted reliefs in the representation of personal integrity, passion, and the human struggle between pride and humility familiar from Dante's Divine Comedy? How can a new interpretation regarding the influence of ancient reliefs and architecture inform the famous "Assisi controversy" and cast new light on the debate around Giotto's authorship of the Saint Francis cycle?"--
Le Corbusier's Maison Curutchet
One of his very few built projects in the Americas, Maison Curutchet is a fascinating representation of Le Corbusier's stylistic transitional period, bridging his late 1920s purism and the maturity of his later work in India. Like Casa Malaparte, this book offers an in-depth analysis of a single building through original documents, drawings, and photographs.
The Complete History of America. Abridged
This play interprets the past as a breathlessly-paced sequence of silly vaudeville sketches ... puns and crude parodies of movie and television genres."
