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Tumor Microenvironment and Cellular Stress
The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
Ovarian Cancer Biomarkers
This book comprehensively summarizes the biology, etiology, and pathology of ovarian cancer and explores the role of deep molecular and cellular profiling in the advancement of precision medicine. The initial chapter discusses our current understanding of the origin, development, progression and tumorigenesis of ovarian cancer. In turn, the book highlights the development of resistance, disease occurrence, and poor prognosis that are the hallmarks of ovarian cancer. The book then reviews the role of deep molecular and cellular profiling to overcome challenges that are associated with the treatment of ovarian cancer. It explores the use of genome-wide association analysis to identify genetic variants for the evaluation of ovarian carcinoma risk and prognostic prediction. Lastly, it highlights various diagnostic and prognostic ovarian cancer biomarkers for the development of molecular-targeted therapy.
Ancient double-entry bookkeeping
A.D. 1494 - the earliest known writer on bookkeeping
The Na+/H+ Exchanger
None
Endocytosis in Plants
Endocytosis is a fundamental cellular process by means of which cells internalize extracellular and plasma membrane cargos for recycling or degradation. It is important for the establishment and maintenance of cell polarity, subcellular signaling and uptake of nutrients into specialized cells, but also for plant cell interactions with pathogenic and symbiotic microbes. Endocytosis starts by vesicle formation at the plasma membrane and progresses through early and late endosomal compartments. In these endosomes cargo is sorted and it is either recycled back to the plasma membrane, or degraded in the lytic vacuole. This book presents an overview of our current knowledge of endocytosis in plants with a main focus on the key molecules undergoing and regulating endocytosis. It also provides up to date methodological approaches as well as principles of protein, structural lipid, sugar and microbe internalization in plant cells. The individual chapters describe clathrin-mediated and fluid-phase endocytosis, as well as flotillin-mediated endocytosis and internalization of microbes. The book was written for a broad spectrum of readers including students, teachers and researchers.
New Urban Configurations
Urban areas have been caught up in a turbulent process of transformation over the past 50 years and changes have been rapid, with issues such as mobility, nature, water management, energy use and public space featuring prominently._x000D_ In each Olympic year since 1988, the Faculty of Architecture at Delft University of Technology has held an international conference focusing on the connection between research and design, exploring the field of tension between science, technology and art._x000D_ This book presents the proceedings of the latest in this series of conferences: New Urban Configurations, held in Delft, the Netherlands, in October 2012 in collaboration with the European Associati...
Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications
The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally d...
Cyrillic Books Printed Before 1701 in British and Irish Collections
The aim of this catalogue is to give particulars and locations of over 200 copies of some 160 works which are preserved in British and Irish collections. Individual features such as bindings and inscriptions have been noted as well as bibliographic descriptions of titles.
Intersecting Health, Livability, and Human Behavior in Urban Environments
The promotion of sustainable urban development and livable cities in the past three decades has effectively merged the themes of urban health, urban sustainability, and urban livability into an integrated research field. As more people are predicted to live in a relatively confined space, the balance between the physical/built environment, social environment, and urban dwellers becomes more delicate. Urban systems have evolved to be more complex than ever during this process. While complex systems often offer relative stability, delicate balance requires carefully designed plans and management to avoid collapse. It is, hence, of great interest and importance to know what future sustainable and livable cities look like. Intersecting Health, Livability, and Human Behavior in Urban Environments considers how to improve the quality of the environment and healthy living in contemporary and future urban environments. Covering key topics such as environmental health, smart cities, and urban health, this premier reference source is ideal for policymakers, government officials, scholars, researchers, academicians, instructors, and students.
