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Drugs for Relapse Prevention of Alcoholism
Alcoholism is a pathological behavioural syndrome, characterised by comp- sive alcohol use, craving and relapses, even recurring after many years of abstinence. It is suggested that chronic alcohol abuse leads to persistent changes within several neurochemical pathways in the brain and furthermore that an imprinted drug and addiction memory may scarcely be extinguished. Hence, the question arises as to whether there ought to be a reasonable hope that pharmacological drugs will be developed that interfere with an addiction memory, and as a result, finally lead to a cure? In this book, leading preclinical and clinical experts in the field of alcohol relapse prevention strive to furnish an answ...
Cannabinoid Modulation of Emotion, Memory, and Motivation
The endocannabinoid system consists of cannabinoid receptors, their endogenous lipid ligands (endocannabinoids) and the enzymatic machinery for their synthesis and degradation. In the brain, endocannabinoids regulate ion channel activity and neurotransmitter release and thereby contribute to various aspects of brain function, including memory, reward and emotions. Their ability to modulate synaptic efficacy has a wide range of functional consequences and provides unique therapeutic possibilities. Unprecedented advances have been made in the understanding of the role of endocannabinoids in the regulation of the emotional brain over the past few years. However, a comprehensive book encompassing all these aspects is still lacking. The book will provide an overview of the role played by the endocannabinoid system in the regulation of emotional processes with particular emphasis on the modulation of memory and reward for emotionally arousing events and for the regulation of motivational aspects in cannabis use.
Insights in Addictive Disorders: 2022
bout This Research Topic is the follow up to Insights in Addictive Disorders: 2021 We are now entering the third decade of the 21st Century, and, especially in the last years, the achievements made by scientists have been exceptional, leading to major advancements in the fast-growing field of Addictive Disorders. Frontiers has organized a series of Research Topics to highlight the latest advancements in research across the field of Addictive Disorders, with articles from the Associate Members of our accomplished Editorial Boards. This editorial initiative of particular relevance, led by Dr. Khazaal, Specialty Chief Editor of the Addictive Disorders section, is focused on new insights, novel ...
The End of Alcohol Addiction
The worldwide burden of alcoholism on affected individuals, their families, and society is enormous. People with alcohol use disorders tend to miss work, get into problems with the law, have financial difficulties, and alienate family and friends. Alcoholism also contributes to health problems such as heart disease, stroke, liver disease, brain damage, pancreatitis, and cancer as well as societal problems such as suicide, domestic violence, and accidents. Some medications help some patients with alcohol addiction, but no drug treatment has been shown to be effective in ending alcohol addiction. One drug, however, has shown promise. Baclofen, which is given for the treatment of multiple scler...
Basic and Clinical Science of Mental and Addictive Disorders
This is the most comprehensive update of basic and clinical information available on mental, addictive and various neurological disorders. Virtually every basic and clinical scientific methodology that is relevant to our understanding and management of brain-related diseases is included in this volume. Readers will find up-to-the-minute studies in functional brain imaging, including MRI and EEG/ERP mapping, the latest application of molecular biology and genetics to solve clinical problems, as well as recent findings on schizophrenia, Alzheimer's disease, drug addiction and alcoholism, suicide and mood disorders. A unique feature of this publication are the nine chapters which examine chroni...
Handbook of Psychiatric Genetics
Psychiatric genetics is an exciting new discipline that explores how our minds and behavior are influenced by our genes. Increased interest in this area of medical genetics has been sparked by advances in molecular genetic techniques, the genome project, the neurosciences, the role of genes in somatic diseases, and the linking of specific genes with complex mental disorders. This Handbook is the definitive resource on this complex, and sometimes controversial, new field.
Logic, Truth and Meaning
Fourth in the series of volumes containing collections of papers of philosopher G.E.M. Anscombe, tackling various subjects and including a reprint of Anscombe's 'Introduction to Wittgenstein's Tractatus'.
When the Servant Becomes the Master
The definitive guide to all things related to addiction and its treatments—newly revised. The updated and revised second edition is a must-read for anyone struggling with addiction, their families, and the professionals who desire to know more about this baffling disease. Jason Powers, MD, approaches addiction from a variety of different angles, clearly and carefully attacking myths and misinformation, and bringing the reader up to date with the most current scientific and popular literature on addiction. Dr. Powers illuminates the entire spectrum of addiction-related topics, from neuroscience to treatment options, and guides the reader through the extensive material and to a more humane y...
Baclofen in the Treatment of Alcohol Use Disorder
This is a collection on use of the GABA-B agonist Baclofen in the use of alcohol use disorder. The articles center around efficacy of Baclofen ranging from acute withdrawal to maintenance of abstinence, address the issue of dosing and indications and variation of Baclofen use worldwide.
