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Modeling the 3D Conformation of Genomes
This book provides a timely summary of physical modeling approaches applied to biological datasets that describe conformational properties of chromosomes in the cell nucleus. Chapters explain how to convert raw experimental data into 3D conformations, and how to use models to better understand biophysical mechanisms that control chromosome conformation. The coverage ranges from introductory chapters to modeling aspects related to polymer physics, and data-driven models for genomic domains, the entire human genome, epigenome folding, chromosome structure and dynamics, and predicting 3D genome structure.
The Organ
Organ, Volume 3 of the Encyclopedia of Keyboard Instruments, includes articles on the organ family of instruments, including famous players, composers, instrument builders, the construction of the instruments and related terminology. It is the first complete reference on this important family of keyboard instruments that predated the piano. The contributors include major scholars of music and musical instruments from around the world.
Optical Networks and Technologies
There has continuously been a massive growth of Internet traffic for these years despite the "bubble burst" in year 2000. As the telecom market is gradually picking up, it would be a consensus in telecom and data-com industries that the CAPEX (Capital Expenditures) to rebuild the network infrastructure to cope with this traffic growth would be imminent, while the OPEX (Operational Expenditures) has to be within a tight constraint. Therefore, the newly built 2r^-century network has to fully evolve from voice-oriented legacy networks, not only by increasing the transmission capacity of WDM links but also by introducing switching technologies in optical domain to provide full-connectivity to su...
The Physics of Cancer
An introduction to the emerging field of cancer physics, integrating cancer biology with approaches from theoretical and applied physics.
Psychotherapy in Pain Management
Within the current opiate crisis, this book provides a timely, comprehensive guide for psychological treatment with chronic pain patients. It is written for academic and practicing psychological professionals, in addition to graduate students, neuroscientists, and neuropsychologists. It provides an explanation of neurophysiological pain processing based the Dimensional Systems Model (DSM), a theory of higher cortical functions. Novel views on the roles of the basal ganglia, cerebellum, and cingulate cortex are presented here, while the applied Clinical Biopsychological Model (CBM) is used to explain psychological treatment with chronic pain patients. Three new areas of treatment focus are discussed in this book, including specific approaches to deal with influential negative emotional memories, interpersonal relationship stressors, and loss-related depression, all of which have been shown to influence chronic pain disorders. Detailed information on how to do assessment, conceptualization, and treatment is also provided. In total, the book offers a unique viewpoint unavailable in any other source.
Malignancies of the Nasal Vestibule
This book provides up-to-date information on nasal vestibule malignancies, outlining the specific clinical history and pattern of spread. It also describes the flaws in TNM staging, which can be attirbuted to factors ranging from the anatomy to the definition of the main prognostic parameters. Nasal vestibule malignancies are associated with a peculiar oncological history, but there are also clear issues related to the reconstructive phase following ablative surgery due to the anatomic peculiarities. Such issues deeply impact the cosmetic and functional results, and hence the quality of life of surviving patients. Additionally, the book describes novel evidence on treatment outcomes for these malignancies in terms of both oncological and functional results. It proposes a new standard based on interstitial HDR brachytherapy for the primary lesion and on surgery for regional metastases. The book appeals to a wide readership, ranging from otolaryngologists, to radiation and clinical oncologists, dermatologists, plastic surgeons and maxillo-facial surgeons.
Bonfire Songs
Fra Girolamo Savonarola had a profound effect on the political and moral life of Florence in the 1490s, and his legacy lived on during the century after his execution in 1498, not just in Florence but in Ferrara and beyond the Alps, as far as Paris, Munich, and London. This study reconstructscontexts and musical settings for the popular tradition of sacred laude that were sung during the Savonarolan carnivals in 1496, 1497, and 1498. It further examines a broad network of patronage for the courtly tradition of Latin motets that provided elaborate musical settings for Savonarola'smeditations on Psalms 30 and 50. The friar's success in Florence can be partially attributed to his adoption of sa...
The Organ Yearbook
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The Organ
The Encyclopedia of Organ includes articles on the organ family of instruments, including famous players, composers, instrument builders, the construction of the instruments, and related terminology. It is the first complete A-Z reference on this important family of keyboard instruments. The contributors include major scholars of music and musical instrument history from around the world.
