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This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neg...
Exploring fundamental concepts, Drug Delivery Nanoparticles Formulation and Characterization presents key aspects of nanoparticulate system development for various therapeutic applications and provides advanced methods used to file for regulatory approval.This comprehensive guide features:Process Analytical Techniques (PAT) used in manufacturing Na
Forgotten People, Forgotten Diseases Second Edition The neglected tropical diseases (NTDs) are the most common infections of the world's poor, but few people know about these diseases and why they are so important. This second edition of Forgotten People, Forgotten Diseases provides an overview of the NTDs and how they devastate the poor, essentially trapping them in a vicious cycle of extreme poverty by preventing them from working or attaining their full intellectual and cognitive development. Author Peter J. Hotez highlights a new opportunity to control and perhaps eliminate these ancient scourges, through alliances between nongovernmental development organizations and private-public part...
This book is a comprehensive treatment of the elastic volumetric response of sandstones to variations in stress. The theory and data presented apply to the deformations that occur, for example, due to withdrawal of fluid from a reservoir, or due to the redistribution of stresses caused by the drilling of a borehole. Although the emphasis is on reservoir-type sandstones, results and methods discussed are also applicable to other porous rocks.Part One concerns the effect of stress on deformation and discusses porous rock compressibility coefficients. Elasticity theory is used to derive relationships between the porous rock compressibility coefficients, the porosity, and the mineral grain compr...
Research into the methods and techniques used in simulating crowds has developed extensively within the last few years, particularly in the areas of video games and film. Despite recent impressive results when simulating and rendering thousands of individuals, many challenges still exist in this area. The comparison of simulation with reality, the realistic appearance of virtual humans and their behavior, group structure and their motion, and collision avoidance are just some examples of these challenges. For most of the applications of crowds, it is now a requirement to have real-time simulations – which is an additional challenge, particularly when crowds are very large. Crowd Simulation...
Faz da trajetória de Antônio P. Rebouças a porta de entrada para se compreender o mundo dos advogados no século XIX, suas ligações com a política e com os grandes debates de seu tempo : a cidadania, o fim da escravidão e a constituição de direitos civis para africanos e seus descendentes.
This book presents empirical analyses of manufacturing firm performance in Africa based on the World Bank Enterprise Survey and on a one-time quantitative survey conducted for the World Bank by the Center for the Study of African Economies of Oxford University.
The Seed of God is a book of transformation and change, with a simple message of motivation and spirituality that excites and assists us to find ways to happiness and the realization of our dreams. A successful businessman feels a emptiness in his life in spite of his fortune. Dispirited, he returns to the neighborhood where was born in an attempt to find his roots. Instead he meets a mysterious lady who inevitably will change his life. For the first time, Renan becomes conscious of the love provided by people surrounding him. Under the old lady's guidance he takes a journey in search of his own spiritual rebirth, preparing himself to become the seed of God.The Seed of God is a sensitive journey of love and peace where no one finishes without feeling touched and renewed, where everything feels within reach.The Seed of God is a powerful book that will affect the life of all its readers. I recommend it. OG MANDINODear friend Cesar Romão, Welcome to the Club of God's gardeners, and may your seeds continue to blossom. PAULO COELHO
A hub for barefoot bohemians and glamorous goddesses, Tulum is a Mayan hideaway that perfectly distills the gypset lifestyle. An off-grid escape for nomadic creatives, it is a playground for spirituality and community. This tiny, idyllic eight-mile strip of sand on Mexico’s Yucatán Peninsula is tucked between a tropical jungle, Mayan ruins, and the Sian Ka’an biosphere: It’s a heady vortex. Tulum’s isolated and breathtakingly beautiful environment also makes it the perfect place for those craving a deeper connection with themselves, others, and nature. Seekers (sun, spiritual, and otherwise) pilgrimage to this beach settlement in droves to join this avant-garde template for a new bohemian lifestyle that prioritizes healing, eco-friendly practices and organic cuisine. The boho-chic crowd’s home away from home, Tulum is a rare and successful modern experiment in both consciousness and sophistication, bolstered by its down-to-earth hotels, mesmerizing cenotes, and lush backdrop.
A generation gap has emerged between parents and their girls. The mothers and fathers of tomorrow’s women have little idea what their daughters are up to sexually or how they feel about it. Drawing on in-depth interviews with more than seventy young women and a wide range of psychologists, academics, and experts, renowned journalist Peggy Orenstein goes where most others fear to tread, pulling back the curtain on the hidden truths, hard lessons, and important possibilities of girls’ sex lives in the modern world.