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Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed. The second volume of the book is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical too...
Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. The first volume comprehensively reviewed current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. In this second volume on Drug Transporters, emphasis is placed on emerging sciences and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potentia...
In this first-of-a-kinf referencek, more than 8,000 Broadway and film soundtracks are listed alphabetically, with complete current pricing for each. Also includes a composer/conductor index, cast index, and valuable tips on how to grade records, sell collections, find rare records, and much more. 8-page color insert.
It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.
CMJ New Music Report is the primary source for exclusive charts of non-commercial and college radio airplay and independent and trend-forward retail sales. CMJ's trade publication, compiles playlists for college and non-commercial stations; often a prelude to larger success.
The only complete statistics of Australia's participation in the Olympic Games from 1896 to 2002. Contains updated and never-before published statistics such as- A complete list of the results for every Australian competitor at every Olympic Games up to Athens in 2004Australia's medal tally from every Olympics Fascinating Olympic factsFamily relationships between every Australian competitor (e.g. brothers/sisters or multiple generations who have competed) Published to be the perfect companion to Harry Gordon's new book on the Sydney Olympics, The Time of our Lives(UQP, October 03). This is an essential handbook to have at your side when watching the 2004 Athens Olympic Games.
The tumultuous 1960s was an era of the counterculture, political activism, and resistance to authority. Conventions and values were challenged and new approaches to education captured the imaginations of parents, teachers, and students. Reacting against the one-size-fits-all nature of the traditional public school system, groups of parents and teachers in Canada and the United States established alternative schools or “free schools” based on the Progressive, child-centred philosophy of John Dewey and the Romantic ideas of Summerhill founder A.S. Neill. In Alternative Schools in British Columbia, 1960-1975, Harley Rothstein tells the story of ten such schools that arose in the province of...
This book takes a look at the 'age of reform', from 1780 when reform became a common object of aspiration, to the 1830s - the era of the 'Reform Ministry' and of the Great Reform Act of 1832 - and beyond, when such aspirations were realized more frequently. It pays close attention to what contemporaries termed 'reform', identifying two strands, institutional and moral, which interacted in complex ways. Particular reforming initiatives singled out for attention include those targeting parliament, government, the law, the Church, medicine, slavery, regimens of self-care, opera, theatre, and art institutions, while later chapters situate British reform in its imperial and European contexts. An extended introduction provides a point of entry to the history and historiography of the period. The book will therefore stimulate fresh thinking about this formative period of British history.