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Mechanisms of Neuroinflammation
"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.
Update on Dementia
The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.
Neurons
The brain is the most complex structure that exists in the universe, consisting of neurons whose function is to receive information through dendrites and transmit information through the axon. In neurosciences one of the main problems that exists are neurodegenerative diseases for which until now there has been no cure. This book is mainly focused on updating the information on the signaling process carried out in the development of axons. Topics such as axon guidance and its interaction with the extracellular matrix are discussed. Other important topics are semaphorins and their relationship with neurodegenerative diseases, and the neurobiology of the gap junction in the dorsal root ganglion. Finally, the topic of bioelectrical interfaces destined to regenerate damaged nerves is covered. The information in this book will be very important both for researchers who work with these issues and doctoral students who are involved in neuroscience.
Topics in Autonomic Nervous System
The nervous system is an essential component of the human body and is divided into two main systems: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and the spinal cord and acts as the command center of the organism. The PNS is a network of nerves that extends from the spinal cord throughout the body and regulates both voluntary and involuntary movements, such as digestion, heart rate, breathing, and body temperature. Within the PNS, there are two subdivisions: the somatic nervous system and the autonomic nervous system. The somatic system controls voluntary movements, while the autonomic system operates automatically and regulates e...
Epilepsy and Alzheimer’s disease: shared pathology, clinical presentations, and targets for treatment
Emerging data suggest a link between Alzheimer’s disease (AD) and epilepsy. AD and other dementias pose increased risk for seizures, with seizure incidence in AD up to ten times greater than in age-matched controls. Mouse models of AD also demonstrate seizures and abnormal spikes or sharp wave discharges (“interictal epileptiform discharges” [IEDs]) on electroencephalography (EEG). Seizures and IEDs may underlie fluctuating cognitive abilities in AD, with the impact of antiseizure medication (ASM) requiring further investigation. Many epilepsy patients have memory and other cognitive deficits, due to multiple factors. Most adult-onset epilepsy occurs in people =60 years of age, and epi...
Advanced Understanding of Neurodegenerative Diseases
Advanced Understanding of Neurodegenerative Diseases focuses on different types of diseases, including Alzheimer's disease, frontotemporal dementia, different tauopathies, Parkinson's disease, prion disease, motor neuron diseases such as multiple sclerosis and spinal muscular atrophy. This book provides a clear explanation of different neurodegenerative diseases with new concepts of understand the etiology, pathological mechanisms, drug screening methodology and new therapeutic interventions. Other chapters discuss how hormones and health food supplements affect disease progression of neurodegenerative diseases. From a more technical point of view, some chapters deal with the aggregation of prion proteins in prion diseases. An additional chapter to discuss application of stem cells. This book is suitable for different readers: college students can use it as a textbook; researchers in academic institutions and pharmaceutical companies can take it as updated research information; health care professionals can take it as a reference book, even patients' families, relatives and friends can take it as a good basis to understand neurodegenerative diseases.
Current Trends in Semantic Web Technologies: Theory and Practice
This book presents innovative and high-quality research regarding the implementation of Semantic Web technologies for knowledge representation and developing intelligent applications in various domains. Semantic Web technologies have inspired many people to create innovative technologies and applications for knowledge representation, Semantic Searches, NLP and Social Networks. The goal of this book is to collect and consolidate novel and high-quality research contributions on Semantic Web technologies and their theoretical and practical application to a range of different domains. In addition to researchers, the book offers a valuable resource for PhD students, master and undergraduate students in IT-related fields such as Computer Science and Information Systems.
Update on Dementia
"The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities."--Provided by publisher
