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Incretin Biology â A Practical Guide
Together, obesity and diabetes form a 21st century epidemic, the treatment of which consumes a substantial fraction of global health costs. New and improved therapies are therefore desperately needed. Incretins are short peptide hormones released from the gut in response to food transit. These hormones regulate a plethora of processes to control food intake, body weight and glucose homeostasis. This is one of the fastest areas of growth within diabetes research, and over the past decade, increasing numbers of novel diabetes drugs — many based on incretin action — have been added to the therapeutic armoury. Following an introduction detailing the historical perspective and discovery of in...
Obesity and Metabolism
It has become increasingly difficult to keep up with the growing body of literature on the genetics, metabolic phenotype and treatment of obesity. This volume brings together an array of chapters from many of the foremost authorities and researchers in this area. Key advances in the genetics of obesity are summarized and the effects of obesity in pregnancy, childhood and old age explored. By scrutinizing the hormones and enzymes most recently implicated in the development, maintenance and consequences of obesity, the biochemical and physiological background of the abnormal metabolism of obesity is mapped out. Furthermore, a practical update on clinical approach and treatment of obesity is offered. Finally, the social aspects of obesity and the view of the obese body in art throughout the centuries are reflected. A valuable overview of causes, metabolic disturbances and treatment options, this volume will appeal to those with an interest in clinical as well as pathophysiological and genetic aspects of obesity. Furthermore, it will provide useful reading for scientists and students who would like to broaden and update their knowledge in this area.
Emerging Roles of Long Noncoding RNAs in Neurological Diseases and Metabolic Disorders
Long noncoding RNAs (lncRNAs) are a new class of transcripts that are in general longer than 200 nucleotides and that have no protein-coding potential. The vast majority of vertebrate genomes encode diverse and complex lncRNAs that play regulatory roles at almost every step of gene expression. Recently, increasing evidence has implicated lncRNAs in the pathogenesis of various human diseases. The purpose of the Research Topic, "Emerging roles of long noncoding RNAs in neurological diseases and metabolic disorders", is to bring together leading researchers in the field who, through contributing to an organized and comprehensive collection of peer-reviewed articles, provide a broad perspective on the latest advances in the field. A number of interesting and cutting-edge areas will be covered as below, but this list is not exclusive: - The methodologies and technologies of identifying and studying lncRNAs - LncRNAs in gene-specific transcription - LncRNAs in epigenetic regulation - LncRNAs in post-transcriptional regulation - LncRNAs in disease - Mapping of noncoding single nucleotide polymorphisms associated with disease.
Cornucopia
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Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism
Volume 542 of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Provides theoretical overview on metabolic alterations of cancer cells, and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo
Melt My Heart
Melt My Heart is a hilarious and inspiring coming-of-age YA novel from Bethany Rutter: influencer, editor and a fierce UK voice in the debate around body positivity. Lily Rose is used to people paying attention to her gorgeous twin sister, Daisy. But even though Lily loves her own fat body, she can't shake the idea that no one would ever choose her over Daisy – not when they could have the thin twin. That is, until she meets Cal, the gorgeous, sweet guy from New Zealand who can't seem to stay away. The gorgeous, sweet guy who also happens to be Daisy's summer crush. Lily can't seem to figure out why she isn't as into him as she should be. She should be head-over-heels in love, not missing time at the ice-cream shack with her life-long best friend, Cassie. Not wondering what Cassie is getting up to with Cal's friend Jack, or what she's thinking about when they're alone . . . With University threatening to tear Cassie and Lily apart at the end of summer and Lily desperately trying to keep Cal a secret from Daisy, summer is set to be far from relaxing.
Rutter's Child and Adolescent Psychiatry
Rutter’s Child and Adolescent Psychiatry has become an established and accepted textbook of child psychiatry. Now completely revised and updated, the fifth edition provides a coherent appraisal of the current state of the field to help trainee and practising clinicians in their daily work. It is distinctive in being both interdisciplinary and international, in its integration of science and clinical practice, and in its practical discussion of how researchers and practitioners need to think about conflicting or uncertain findings. This new edition now offers an entirely new section on conceptual approaches, and several new chapters, including: neurochemistry and basic pharmacology brain imaging health economics psychopathology in refugees and asylum seekers bipolar disorder attachment disorders statistical methods for clinicians This leading textbook provides an accurate and comprehensive account of current knowledge, through the integration of empirical findings with clinical experience and practice, and is essential reading for professionals working in the field of child and adolescent mental health, and clinicians working in general practice and community pediatric settings.
Why We Lost
A high-ranking general's gripping insider account of the U.S. wars in Iraq and Afghanistan, and how it all went wrong. Over a thirty-five-year career, Daniel Bolger rose through the army infantry to become a three-star general, commanding in both theaters of the U.S. campaigns in Iraq and Afghanistan. He participated in meetings with top-level military and civilian players, where strategy was made and managed. At the same time, he regularly carried a rifle alongside rank-and-file soldiers in combat actions, unusual for a general. Now, as a witness to all levels of military command, Bolger offers a unique assessment of these wars, from 9/11 to the final withdrawal from the region. Writing with hard-won experience and unflinching honesty, Bolger makes the firm case that in Iraq and in Afghanistan, we lost -- but we didn't have to. Intelligence was garbled. Key decision makers were blinded by spreadsheets or theories. And, at the root of our failure, we never really understood our enemy. Why We Lost is a timely, forceful, and compulsively readable account of these wars from a fresh and authoritative perspective.
