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In keeping with the broad objectives set for the serial publication of Advances in Structural Biology, Volume 6 contains exhaustive articles from experts in diverse areas of biomedical research. The common thread among the various articles is their relevance to the applications of cell biology to human health.
There exists a profound conflict at the heart of oncology drug development. The efficiency of the drug development process is falling, leading to higher costs per approved drug, at the same time personalised medicine is limiting the target market of each new medicine. Even as the global economic burden of cancer increases, the current paradigm in drug development is unsustainable. In this book, we discuss the development of techniques in machine learning for improving the efficiency of oncology drug development and delivering cost-effective precision treatment. We consider how to structure data for drug repurposing and target identification, how to improve clinical trials and how patients may view artificial intelligence.
This book presents the proceedings of the Gmunden Retreat on NeuroIS 2015, reporting on topics at the intersection of Information Systems (IS) research, neurophysiology and the brain sciences. Readers will discover the latest findings from top scholars in the field of NeuroIS, which offer detailed insights on the neurobiology underlying IS behavior, essential methods and tools and their applications for IS, as well as the application of neuroscience and neurophysiological theories to advance IS theory.
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This book discusses the most significant recent advances in oncological molecular imaging, covering the full spectrum from basic and preclinical research to clinical practice. The content is divided into five sections, the first of which is devoted to standardized and emerging technologies and probe designs for different modalities, such as PET, SPECT, optical and optoacoustic imaging, ultrasound, CT, and MRI. The second section focuses on multiscale preclinical applications ranging from advanced microscopy and mass spectroscopy to whole-body imaging. In the third section, various clinical applications are presented, including image-guided surgery and the radiomic analysis of multiple imaging features. The final two sections are dedicated to the emerging, crucial role that molecular imaging can play in the planning and monitoring of external and internal radiotherapy, and to future challenges and prospects in multimodality imaging. Given its scope, the handbook will benefit all readers who are interested in the revolution in diagnostic and therapeutic oncology that is now being brought about by molecular imaging.
The Amino Sugars: The Chemistry and Biology of Compounds Containing Amino Sugars, Volume IIA: Distribution and Biological Role focuses on the chemistry, physical chemistry, and biochemistry of naturally occurring and synthetically prepared amino sugars and amino sugar-containing molecules, as well as the biological and medical importance of these molecules. The selection first offers information on the distribution of amino sugars in microorganisms, plants, and invertebrates and amino sugars and macromolecules containing amino sugars in liver. Discussions focus on microorganisms, invertebrates, amino sugar composition, catabolism of amino sugars, and metabolic interrelationships between amin...
Includes section, "Recent book acquisitions" (varies: Recent United States publications) formerly published separately by the U.S. Army Medical Library.