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Progress in Immunology
Never has so much progress been reported in immunology as at this congress. The full impact of new technologies, developed since the late 1970s, has come to fruition: gene isolation, mutation, transfection and expression, protein structure and peptide synthesis, cell cloning, hybridization and monoclonal antibodies, CD serology, SCID and transgenic mice, modern immunomudulation and vaccines. An overwhelming mass of data has accumulated over the last years. The reports are up-to-date and outstanding, to a degree no journal will ever achieve, and the results are presented in a concise and lucid way. This report will serve as a guideline for generations of immunologists to come. Hundreds of new alleys have been opened, an abundance of research tools and goals are pointed to. This volume is a treasure trove of explorations ahead of our time - it is exciting reading. This progress report presents outstanding contributions, worth many prizes - a feature which is unusual for proceedings volumes. Immunology is exhibited at its best: an exciting research area and a rewarding subject to study for the benefit of mankind - today more than ever!
T Cell Hybridomas
For more than ten years cell fusion techniques have been applied in studies on various lymphocyte functions. Ig expression was first studied in hybrids obtained by fusing myeloma cells with fibroblasts (1) or lymphomas (2), both of which do not produce Ig, and with Ig producing myelomas (3) or human blood lymphocytes (4). Kohler and Milstein (5) fused a myeloma with spleen cells from immunized mice. Up to 10% of the hybrids obtained secreted antibodies specific for the immunizing antigen. This suggested that plasma cells preferenti ally fused with the myeloma cells, a finding which was of enormous practical value. It was found that both Band T lymphocytes could be fused with the T cell tumor...
Advances in Cancer Research
Advances in Cancer Research
The Biochemistry of Cell Signalling
A comprehensive study of the principles of cell signalling, concentrating on the structural and mechanistic aspects. The book is divided into four parts describing the machinery of signal transduction, the implementation of the signalling cascades focussing on the effect on gene transcription, the globular cellular regulatory programs, and the loss of regulatory control and its consequences with repsect to the molecular basis of cancer. There are well over 200 figures, many in 3-D representations.
Symposium in Immunology I and II
The Symposia in Immunology were organized to bring important new information in the expanding field of immunology to practicing physicians interested in the field. Highly renowned basic scientists share their results with physicians conducting clinical research and thoses experienced in the treatment of the respective diseases. This series of symposia will cover different areas of immunology and will help to close the gap between the special achievements of scientists and the daily routine of practicing physicians.
EJB Reviews 1990
In the mid-1980s the European Journal of Biochemistry set out to publish review articles. The enterprise proved successful resulting in high-level reviews written by well-known scientists appearing in the Journal. The reviews represent emerging and rapidly growing fields of research in fundamental as well as applied areas of biochemistry, such as medicine, biotechnology, agriculture and nutrition. Novel methodological and technological approaches which stimulate biochemical research are also included. The authors of the reviews are explicitly asked to be critical, selective, evaluative and interdisciplinarily oriented. The reviews should encourage young scientists toward independent and creative thinking, and inform active investigators about the state of the art in a given field.
EJB Reviews 1993
In the mid-1980s the European Journal of Biochemistry set out to publish review articles. The enterprise proved successful, resulting in high-level reviews written by well-known scientists appearing in the Journal. The reviews represent emerging and rapidly growing fields of research in fundamental as well as applied areas of biochemistry, such as medicine, biotechnology, agriculture and nutrition. Novel methodological and technological approaches which stimulate biochemical research are also included. The authors of the reviews are explicitly asked to be critical, selective, evaluative and interdisciplinarily oriented. The reviews should encourage young scientists to think independently and creatively, and inform active investigators about the state of the art in a given field.
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine
Scientists believe that stem cells have the potential to revolutionize the treatment of numerous diseases and conditions. This guide covers recent advances in technologies and their applications in stem cell biology, addressing the use of both embryonic and adult stem cells and discussing diverse technologies, including genome-wide expression analysis, informatics, chemical genomics, and more. Applications covered encompass self-renewal, differentiation, reprogramming, and regeneration in model organisms. This is a premier reference for practicing professionals involved in stem cell research and students.
Apoptosis
The fifth Annual Pezcoller Symposium entitled, Apoptosis, was held in Trento, Italy, June 9-1I, 1993 and was focused on the specific phenomena leading to Programmed Cell Death (PCD) or Apoptosis, and the mechanisms involved. With presentations at the cutting edge of progress and stimulating discussions, this Symposium addressed the genetics and molecular mechanisms determining PCD and the role of this suicidal process in cancer and the immune system. The functions of pS3, c myc and bel 2 in affecting apoptosis in different cell types and the role of ions and intracellular pH changes and that of intranuelear endonueleases are given particular emphasis as are the effects of anticancer agents, ...
