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More Practical Problem Solving in HPLC
A unique approach to solving HPLC problems. Everyone who bought "Problem Solving in HPLC" by Stavros Kromidas will equally benefit from nearly 100 new practical examples for optimization, trouble-shooting, and instrument performance given in this sequel. The author provides - guidance for selecting and evaluating methods, intstruments and columns, - practical help with everyday trouble-shooting, - advice for optimizing separations, always explaining the reason why. In each case the problem, the solution and the conclusions are presented over a maximum of 4 pages, and in addition the book contains manufacturers' addresses, references, data tables and checklists.
Quantification in LC and GC
Closing a gap in the current literature by addressing the evaluation and quality assessment of raw data, this practice-oriented guide is clearly divided into three parts. The first describes basic considerations of chromatographic data quality, common errors and potential pitfalls in reading out and quantifying the data. Part two systematically covers the most important chromatographic methods as well as the specific requirements for obtaining good chromatographic data. The final part looks at data quality from the perspective of those regulatory authorities demanding certain standards in data quality, describing in detail best practices. Written with the practitioner in mind, the text not only teaches the mathematical basics but also provides invaluable advice.
The HPLC Expert
The rapid development of HPLC instrumentation and technology opens numerous possibilities - and entails new questions. Which column should I choose to obtain best results, which gradient fits to my analytical problem, what are recent and promising trends in detection techniques, what is state of the art regarding LC-MS coupling? All these questions are answered by experts in ten self-contained chapters. Besides these more hardware-related and technical chapters, further related areas of interest are covered: Comparison of recent chromatographic data systems and integration strategies, smart documentation, efficient information search in internet, and tips for a successful FDA inspection. This practical approach offers in a condensed manner recent trends and hints, and will also display the advanced reader mistakes and errors he was not aware of so far.
Gradient HPLC for Practitioners
This practical guide for analytical scientists explains the use of gradients in liquid chromatography. The fundamentals of gradient separations, as well as the most common application scenarios are addressed, from LC-MS coupling to biochromatography to the separation of ionic substances. Throughout, this handy volume provides detailed hands-on information for practitioners, enabling them to use gradient separation methods reliably and efficiently.
Practice of High Performance Liquid Chromatography
During its short 20 year history High Performance Liquid Chro matography (HPLC) has won itself a firm place amongst the instrumental methods of analysis. HPLC has caused a revolution in biological and pharmaceutical chemistry. Approximately two thirds of the publications on HPLC are concerned with problems from this area of life science. Biotechnology, where it is necessary to isolate substances from complicated mixtures, is likely to give further impetus to the dissemination of modern liquid chromatog raphy in columns, particularly on the preparative scale. This book presents, by means of examples, the application of HPLC to various fields, as well as fundamental discussions of chromatograp...
HPLC Made to Measure
The only topical HPLC book to focus on optimization, this volume addresses the needs of HPLC users who wish to constantly improve their methods, in particular in terms of throughput, accuracy and cost-effectiveness. This handbook features contributions from such bestselling authors as John W. Dolan, Michael McBrien, Veronika R. Meyer, Uwe D. Neue, Lloyd R. Snyder, and Klaus K. Unger, as well as from scientists working for major companies, including Agilent, AstraZeneca, Merck, Schering, Tosoh Biosep, VWR, and Waters. It covers essential aspects of optimization in general, optimization in different LC-modi, hyphenated techniques and computer-aided optimization. The whole is rounded off with a section of user reports.
Paleobiodiversity and Tectono-Sedimentary Records in the Mediterranean Tethys and Related Eastern Areas
This edited volume contains the best papers accepted for presentation during the 1st Springer Conference of the Arabian Journal of Geosciences (CAJG-1), Tunisia 2018. The volume shares the latest results from paleontological, biostratigraphic and sedimentological studies by experienced researchers mainly from research institutes in the Mediterranean and Middle East. Main topics include: paleontology, biostratigraphy, sedimentology, paleoclimatology and geomorphology. Some new insights are given on paleobiodiversity and major biological tools for biostratigraphy, patterns, mechanisms and processes of meso-cenozoic sedimentation in the Mediterranean and Middle East. In particular, case studies are included to highlight the major controlling factors of Tethyan biosphere-geosphere interactions as inferred from the Mediterranean and Middle East regions. The book is of interest to all researchers in the fields of different disciplines involved in the sedimentary geology.
Computational Knowledge Discovery for Bioinformatics Research
"This book discusses the most significant research and latest practices in computational knowledge discovery approaches to bioinformatics in a cross-disciplinary manner that is useful for researchers, practitioners, academicians, mathematicians, statisticians, and computer scientists involved in the many facets of bioinformatics"--
Handbuch Validierung in der Analytik
Als vor mehr als einem Jahrzehnt die erste Auflage dieses Buches erschien, war Validierung für viele Laborleiter eine Herausforderung. Nun haben die Weiterentwicklungen von Methoden und die Ansprüche an die Verlässlichkeit und Übertragbarkeit von Messergebnissen die Validierung als festen Bestandteil etabliert. Damit stehen Laborleitung und Qualitätsmanagement vor den Fragen wie: * Was muss unbedingt validiert werden und welche Aussagekraft haben Validierungsdaten? * Was wird von wem vorgegeben und wo sind wir frei? * Wie können wir schnell und kostengünstig, aber richtig validieren? Die Antworten lassen sich mit der zweiten Auflage dieses Handbuchs noch besser finden. Bewährtes wurd...
HPLC richtig optimiert
Neben der Methodenentwicklung ist die Optimierung bestehender Methoden eine zentrale Aufgabe im HPLC-Labor. Eine Aufgabe, die heute in immer kürzerer Zeit und kosteneffizient erledigt werden muss. Das Handbuch bietet eine fundierte Hilfe, um diese Herausforderung noch besser zu meistern. International renommierte Autoren wie John W. Dolan, Michael McBrien, Veronika R. Meyer, Uwe D. Neue, Lloyd R. Snyder oder Klaus K. Unger behandeln sowohl die allgemeinen Grundlagen und Strategien der Optimierung als auch die spezifischen Aspekte der unterschiedlichen Techniken wie RP-HPLC, NP-HPLC, Micro- und Nano-HPLC sowie der Kopplungstechniken wie LC-MS. Auch die richtige Säulenauswahl sowie Enantiome...
