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Potassium Channels in Cardiovascular Biology
  • Language: en
  • Pages: 962

Potassium Channels in Cardiovascular Biology

Potassium channels (K+) are membrane-spanning proteins which serve many important functions and are becoming a hot topic in physiology. K+ channels determine or modulate many functions of vascular smooth muscle, endothelial and inflammatory cells, and thus are central to regulation of arterial tone and control of cell proliferation. They are also promising targets for antihypertensive treatments with drugs which open and close specific types of K+ channels, making for an active field of research. With their ability to control vascular tone, voltage-gated K+ channels play a significant role in both pulmonary and systemic hypertension as well as in cardiac arrhythmias. This book will highlight the latest discoveries by leading researchers pertaining to the role of K+ channels in the heart and blood vessels in normal physiology and a variety of disease states.

Flexible Viruses
  • Language: en
  • Pages: 532

Flexible Viruses

This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.

Measles
  • Language: en
  • Pages: 201

Measles

Measles virus, one of the most contagious of all human viruses, has been largely contained by the development and use of a vaccine that was introduced 50 years ago. These two volumes were timed to honor the introduction of the vaccine and to record the enormous advancements made in understanding the molecular and cell biology, pathogenesis, and control of this infectious disease. Where vaccine has been effectively delivered, endemic measles virus transmission has been eliminated. However, difficulties in vaccine delivery, lack of health care support and objection to vaccination in some communities continue to result in nearly 40 million cases and over 300,000 deaths per year from measles.

Measles Virus Nucleoprotein
  • Language: en
  • Pages: 180

Measles Virus Nucleoprotein

Measles virus possesses a non segmented, single stranded, negative sense RNA genome that is encapsidated by the nucleoprotein to form a helical nucleocapsid. This ribonucleoproteic complex is the substrate for both transcription and replication. The RNA-dependent RNA polymerase binds to the nucleocapsid template via its co-factor, the phosphoprotein. This book focuses on the main structural information available on the nucleoprotein, showing that it consists of a structured core (NCORE) and of an intrinsically disordered C-terminal domain (NTAIL). The functional implications of the disordered nature of NTAIL are discussed in light of the ability of disordered regions to establish interaction...

NMR in Structural Biology
  • Language: en
  • Pages: 770

NMR in Structural Biology

The volume presents a survey of the research by Kurt Wthrich and his associates during the period 1965 to 1994. A selection of reprints of original papers on the use of NMR spectroscopy in structural biology is supplemented with an introduction, which outlines the foundations and the historical development of the use of NMR spectroscopy for the determination of three-dimensional structures of biological macromolecules in solution. The original papers are presented in groups highlighting protein structure determination by NMR, studies of dynamic properties and hydration of biological macromolecules, and practical applications of the NMR methodology in fields such as enzymology, transcriptional regulation, immunosuppression and protein folding.

Negative Strand RNA Virus
  • Language: en
  • Pages: 323

Negative Strand RNA Virus

Negative strand RNA viruses have a unique mechanism of replication. Their genome is a single strand RNA that has to be transcribed as soon as the virus enters the host in order to carry out viral replication. As a result, a viral-specific RNA polymerase is packaged in the virion and is ready for transcription after virus entry. This novel replication mechanism dictates the assembly and RNA synthesis of negative strand RNA viruses. In recent years, many discoveries have been made with regard to the entry, replication and assembly of this class of viruses. This book will present updated coverage of the fundamental knowledge about negative strand RNA viruses.

Peptides 1992
  • Language: en
  • Pages: 1066

Peptides 1992

  • Type: Book
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  • Published: 1993-06-30
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  • Publisher: Springer

Proceedings of the Twenty-Second European Peptide Symposium, September 13-19, 1992, Interlaken, Switzerland

Molecular Biology of the Cell
  • Language: en
  • Pages: 752

Molecular Biology of the Cell

  • Type: Book
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  • Published: 2007
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  • Publisher: Unknown

MBC online publishes papers that describe and interpret results of original research conserning the molecular aspects of cell structure and function.

Chemistry, 2001-2005
  • Language: en
  • Pages: 500

Chemistry, 2001-2005

A collection of the Nobel Lectures delivered by the prizewinners in chemistry, together with their biographies, portraits and the presentation speeches.

Les Prix Nobel
  • Language: en
  • Pages: 572

Les Prix Nobel

  • Type: Book
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  • Published: 2002
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  • Publisher: Unknown

Vol. for 1901 has a sketch of Alfred Nobel and his works, by P.T. Cleve.